人 KAP1 抗体对
01AB00612
Tripartite motif containing 28 (TRIM28), also known as KAP1 or TIF1β, is a multi-domain protein that primarily functions as a transcriptional co-repressor. It belongs to the TRIM family and features a RING domain, two B-boxes, and a coiled-coil region, which are essential for its role in chromatin remodeling and gene regulation. TRIM28 interacts with KRAB-ZFPs (KRAB domain-containing zinc finger proteins) to repress transcription by modifying chromatin structure and recruiting histone deacetylases. Additionally, TRIM28 exhibits E3 ubiquitin ligase activity, allowing it to ubiquitinate various substrates, thereby influencing cellular signaling pathways. Its dysregulation has been implicated in several diseases, particularly cancer, where TRIM28 is associated with tumor progression and maintenance of cancer stem cell properties. Furthermore, it plays a role in the DNA damage response and apoptosis regulation.
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技术参数
- 靶点基因名
- TRIM28
- 基因别名
- KAP1; RNF96; TIF1B
- 蛋白别名
- tripartite motif containing 28; KAP1
- UniProt
- Q13263
- 物种
- Human
产品详情
- 靶点名称
- KAP1
- 蛋白名称
- tripartite motif containing 28
- 蛋白别名
- Transcription intermediary factor 1-beta; TIF1-beta; E3 SUMO-protein ligase TRIM28; KRAB-associated protein 1; KAP-1; KRAB-interacting protein 1; KRIP-1; Nuclear corepressor KAP-1; RING finger protein 96; RING-type E3 ubiquitin transferase TIF1-beta; Tripartite motif-containing protein 28
- 靶点基因名
- TRIM28
- 基因别名
- KAP1; RNF96; TIF1B
- UniProt
- Q13263
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Tripartite motif containing 28 (TRIM28), also known as KAP1 or TIF1β, is a multi-domain protein that primarily functions as a transcriptional co-repressor. It belongs to the TRIM family and features a RING domain, two B-boxes, and a coiled-coil region, which are essential for its role in chromatin remodeling and gene regulation. TRIM28 interacts with KRAB-ZFPs (KRAB domain-containing zinc finger proteins) to repress transcription by modifying chromatin structure and recruiting histone deacetylases. Additionally, TRIM28 exhibits E3 ubiquitin ligase activity, allowing it to ubiquitinate various substrates, thereby influencing cellular signaling pathways. Its dysregulation has been implicated in several diseases, particularly cancer, where TRIM28 is associated with tumor progression and maintenance of cancer stem cell properties. Furthermore, it plays a role in the DNA damage response and apoptosis regulation.