抗人 JADE3 抗体对
01AB01972
Jade family PHD finger 3 (JADE3) is a nuclear protein characterized by tandem plant homeodomain (PHD)-type zinc fingers, which are essential for its role as a chromatin-associated transcriptional regulator. It serves as a critical scaffold subunit for HBO1 (KAT7) histone acetyltransferase complexes, facilitating the acetylation of histone H4 to modulate chromatin structure and gene expression. Through alternative splicing, JADE3 produces multiple transcript variants that maintain its core biochemical functions in chromatin-modifying pathways. Clinically, JADE3 has been identified as an oncogenic driver in colon cancer, where it promotes the acquisition of cancer stem cell-like traits, thereby supporting tumor progression and resistance to therapy.
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技术参数
- 靶点基因名
- JADE3
- 基因别名
- KIAA0215; PHF16
- 蛋白别名
- jade family PHD finger 3; JADE3
- UniProt
- Q92613
- 物种
- Human
产品详情
- 靶点名称
- JADE3
- 蛋白名称
- jade family PHD finger 3
- 蛋白别名
- Protein Jade-3; Jade family PHD finger protein 3; PHD finger protein 16
- 靶点基因名
- JADE3
- 基因别名
- KIAA0215; PHF16
- UniProt
- Q92613
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Jade family PHD finger 3 (JADE3) is a nuclear protein characterized by tandem plant homeodomain (PHD)-type zinc fingers, which are essential for its role as a chromatin-associated transcriptional regulator. It serves as a critical scaffold subunit for HBO1 (KAT7) histone acetyltransferase complexes, facilitating the acetylation of histone H4 to modulate chromatin structure and gene expression. Through alternative splicing, JADE3 produces multiple transcript variants that maintain its core biochemical functions in chromatin-modifying pathways. Clinically, JADE3 has been identified as an oncogenic driver in colon cancer, where it promotes the acquisition of cancer stem cell-like traits, thereby supporting tumor progression and resistance to therapy.