人 ITSN2 抗体对
01AB02484
Intersectin 2 (ITSN2) is a large cytoplasmic scaffold and adaptor protein that regulates clathrin-mediated endocytosis and actin cytoskeletal dynamics. It contains multiple functional domains, including EH, coiled-coil, and SH3 domains, which enable extensive protein-protein interactions. ITSN2 facilitates the formation and maturation of clathrin-coated vesicles and is particularly involved in T cell antigen receptor (TCR) endocytosis. By interacting with partners such as Cdc42 and WASp, it links endocytic membranes to the actin assembly machinery. Through these mechanisms, ITSN2 integrates endocytosis with intracellular signaling pathways and vesicle trafficking. Dysregulation of intersectin proteins has been associated with tumor progression in various cancers and with neurodegenerative conditions such as Down syndrome and Alzheimer’s disease.
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技术参数
- 靶点基因名
- ITSN2
- 基因别名
- KIAA1256; SH3D1B; SWAP
- 蛋白别名
- intersectin 2; ITSN2
- UniProt
- Q9NZM3
- 物种
- Human
产品详情
- 靶点名称
- ITSN2
- 蛋白名称
- intersectin 2
- 蛋白别名
- Intersectin-2; SH3 domain-containing protein 1B; SH3P18; SH3P18-like WASP-associated protein
- 靶点基因名
- ITSN2
- 基因别名
- KIAA1256; SH3D1B; SWAP
- UniProt
- Q9NZM3
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Intersectin 2 (ITSN2) is a large cytoplasmic scaffold and adaptor protein that regulates clathrin-mediated endocytosis and actin cytoskeletal dynamics. It contains multiple functional domains, including EH, coiled-coil, and SH3 domains, which enable extensive protein-protein interactions. ITSN2 facilitates the formation and maturation of clathrin-coated vesicles and is particularly involved in T cell antigen receptor (TCR) endocytosis. By interacting with partners such as Cdc42 and WASp, it links endocytic membranes to the actin assembly machinery. Through these mechanisms, ITSN2 integrates endocytosis with intracellular signaling pathways and vesicle trafficking. Dysregulation of intersectin proteins has been associated with tumor progression in various cancers and with neurodegenerative conditions such as Down syndrome and Alzheimer’s disease.