人 ITIH1 抗体对
01AB02207
Inter-alpha-trypsin inhibitor heavy chain 1 (ITIH1) is a liver-derived, secreted glycoprotein that serves as a core component of the inter-alpha-trypsin inhibitor (IαI) complex. It plays a critical role in extracellular matrix stabilization by covalently linking to hyaluronan (HA) via a chondroitin sulfate-bearing light chain. This ITIH1-HA complex is essential for tissue repair, inflammation, and reproductive processes such as ovulation. ITIH1 also supports cell adhesion through interactions with vitronectin and fibronectin. Clinically, elevated ITIH1 levels are associated with systemic insulin resistance, as its deposition on HA around adipose and muscle tissues creates a physical barrier to insulin signaling. Furthermore, genetic data link the ITIH family to psychiatric disorders and autosomal recessive intellectual developmental disorder 5.
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技术参数
- 靶点基因名
- ITIH1
- 基因别名
- IGHEP1
- 蛋白别名
- inter-alpha-trypsin inhibitor heavy chain 1; ITIH1
- UniProt
- P19827
- 物种
- Human
产品详情
- 靶点名称
- ITIH1
- 蛋白名称
- inter-alpha-trypsin inhibitor heavy chain 1
- 蛋白别名
- Inter-alpha-trypsin inhibitor heavy chain H1; ITI heavy chain H1; ITI-HC1; Inter-alpha-inhibitor heavy chain 1; Inter-alpha-trypsin inhibitor complex component III; Serum-derived hyaluronan-associated protein; SHAP
- 靶点基因名
- ITIH1
- 基因别名
- IGHEP1
- UniProt
- P19827
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Inter-alpha-trypsin inhibitor heavy chain 1 (ITIH1) is a liver-derived, secreted glycoprotein that serves as a core component of the inter-alpha-trypsin inhibitor (IαI) complex. It plays a critical role in extracellular matrix stabilization by covalently linking to hyaluronan (HA) via a chondroitin sulfate-bearing light chain. This ITIH1-HA complex is essential for tissue repair, inflammation, and reproductive processes such as ovulation. ITIH1 also supports cell adhesion through interactions with vitronectin and fibronectin. Clinically, elevated ITIH1 levels are associated with systemic insulin resistance, as its deposition on HA around adipose and muscle tissues creates a physical barrier to insulin signaling. Furthermore, genetic data link the ITIH family to psychiatric disorders and autosomal recessive intellectual developmental disorder 5.