人 ITGB7 抗体对
01AB00862
Integrin subunit beta 7 (ITGB7) is a transmembrane glycoprotein encoded by the ITGB7 gene, playing a critical role in cell adhesion and immune regulation. It pairs with alpha subunits ITGA4 (forming α4β7) or ITGAE (forming αEβ7), creating receptors that mediate lymphocyte migration and homing to gut-associated lymphoid tissues (GALT). The extracellular domain of ITGB7 contains an I-like domain for ligand binding, a PSI domain, hybrid domain, EGF repeats, and a β-tail domain. These structural features enable interactions with adhesion molecules like MAdCAM-1 and E-cadherin, facilitating mucosal immunity and epithelial binding. ITGB7 dynamically regulates ligand affinity through conformational changes and interacts with intracellular signaling proteins via its cytoplasmic tail. Clinically, ITGB7 is implicated in inflammatory bowel diseases due to its role in lymphocyte trafficking to inflamed gut tissues.
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技术参数
- 靶点基因名
- ITGB7
- 蛋白别名
- integrin subunit beta 7; ITGB7
- UniProt
- P26010
- 物种
- Human
产品详情
- 靶点名称
- ITGB7
- 蛋白名称
- integrin subunit beta 7
- 蛋白别名
- Integrin beta-7; Gut homing receptor beta subunit
- 靶点基因名
- ITGB7
- UniProt
- P26010
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Integrin subunit beta 7 (ITGB7) is a transmembrane glycoprotein encoded by the ITGB7 gene, playing a critical role in cell adhesion and immune regulation. It pairs with alpha subunits ITGA4 (forming α4β7) or ITGAE (forming αEβ7), creating receptors that mediate lymphocyte migration and homing to gut-associated lymphoid tissues (GALT). The extracellular domain of ITGB7 contains an I-like domain for ligand binding, a PSI domain, hybrid domain, EGF repeats, and a β-tail domain. These structural features enable interactions with adhesion molecules like MAdCAM-1 and E-cadherin, facilitating mucosal immunity and epithelial binding. ITGB7 dynamically regulates ligand affinity through conformational changes and interacts with intracellular signaling proteins via its cytoplasmic tail. Clinically, ITGB7 is implicated in inflammatory bowel diseases due to its role in lymphocyte trafficking to inflamed gut tissues.