人 ITGB6 抗体对
01AB03260
Integrin beta-6 (ITGB6) is a protein that encodes the β6 subunit of the integrin αvβ6, a heterodimeric glycoprotein involved in cell adhesion and signaling. This integrin is primarily expressed in epithelial cells and plays a crucial role in various biological processes, including tissue repair, inflammation, and the activation of transforming growth factor-beta (TGF-β1), which is essential for wound healing and fibrosis. ITGB6 facilitates the conversion of latent TGF-β1 into its active form, influencing processes such as cell proliferation and epithelial-mesenchymal transition (EMT). Dysregulation of ITGB6 has been linked to several diseases, particularly in cancer, where its overexpression can promote tumor progression and metastasis by enhancing cell migration and invasion. Additionally, mutations in the ITGB6 gene have been associated with amelogenesis imperfecta, a genetic disorder affecting tooth enamel formation.
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技术参数
- 靶点基因名
- ITGB6
- 蛋白别名
- integrin subunit beta 6; ITGB6
- UniProt
- P18564
- 物种
- Human
产品详情
- 靶点名称
- ITGB6
- 蛋白名称
- integrin subunit beta 6
- 蛋白别名
- Integrin beta-6
- 靶点基因名
- ITGB6
- UniProt
- P18564
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Integrin beta-6 (ITGB6) is a protein that encodes the β6 subunit of the integrin αvβ6, a heterodimeric glycoprotein involved in cell adhesion and signaling. This integrin is primarily expressed in epithelial cells and plays a crucial role in various biological processes, including tissue repair, inflammation, and the activation of transforming growth factor-beta (TGF-β1), which is essential for wound healing and fibrosis. ITGB6 facilitates the conversion of latent TGF-β1 into its active form, influencing processes such as cell proliferation and epithelial-mesenchymal transition (EMT). Dysregulation of ITGB6 has been linked to several diseases, particularly in cancer, where its overexpression can promote tumor progression and metastasis by enhancing cell migration and invasion. Additionally, mutations in the ITGB6 gene have been associated with amelogenesis imperfecta, a genetic disorder affecting tooth enamel formation.