人 ITGB1BP1 抗体对
01AB01743
Integrin subunit beta 1 binding protein 1 (ITGB1BP1) is a cytoplasmic adaptor protein that specifically regulates integrin-mediated cell-matrix interactions by binding to the β1 integrin cytoplasmic tail. It utilizes a C-terminal phosphotyrosine-binding (PTB) domain to compete with other activators like talin and kindlins, thereby negatively regulating the activation and clustering of α5β1 integrin. Through this mechanism, ITGB1BP1 modulates focal adhesion assembly, cell spreading, migration, and angiogenesis. It also integrates mechanical cues with signaling pathways such as MAPK/ERK and Notch to fine-tune cellular proliferation. Pathogenic variants in ITGB1BP1 are associated with cerebral cavernous malformations and immunodeficiency 49, highlighting its critical roles in maintaining vascular integrity and supporting immune system function.
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技术参数
- 靶点基因名
- ITGB1BP1
- 基因别名
- ICAP1
- 蛋白别名
- integrin subunit beta 1 binding protein 1; ITGB1BP1
- UniProt
- O14713
- 物种
- Human
产品详情
- 靶点名称
- ITGB1BP1
- 蛋白名称
- integrin subunit beta 1 binding protein 1
- 蛋白别名
- Integrin beta-1-binding protein 1; Integrin cytoplasmic domain-associated protein 1; ICAP-1
- 靶点基因名
- ITGB1BP1
- 基因别名
- ICAP1
- UniProt
- O14713
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Integrin subunit beta 1 binding protein 1 (ITGB1BP1) is a cytoplasmic adaptor protein that specifically regulates integrin-mediated cell-matrix interactions by binding to the β1 integrin cytoplasmic tail. It utilizes a C-terminal phosphotyrosine-binding (PTB) domain to compete with other activators like talin and kindlins, thereby negatively regulating the activation and clustering of α5β1 integrin. Through this mechanism, ITGB1BP1 modulates focal adhesion assembly, cell spreading, migration, and angiogenesis. It also integrates mechanical cues with signaling pathways such as MAPK/ERK and Notch to fine-tune cellular proliferation. Pathogenic variants in ITGB1BP1 are associated with cerebral cavernous malformations and immunodeficiency 49, highlighting its critical roles in maintaining vascular integrity and supporting immune system function.