人 ITGB1 抗体对
01AB03684
Integrin subunit beta 1 (ITGB1) is a vital component of the integrin family, functioning as a transmembrane glycoprotein that forms heterodimers with various alpha subunits, facilitating crucial cellular processes such as adhesion, migration, and signaling. ITGB1 plays a significant role in numerous physiological functions, including embryogenesis and tissue repair, and is implicated in the pathogenesis of several diseases, notably cancers like gallbladder and breast cancer. Dysregulation of ITGB1 has been linked to tumor progression and metastasis, making it a potential prognostic biomarker and therapeutic target. The gene encoding ITGB1 is located on chromosome 10p11.22 and produces multiple isoforms, with the β1-A isoform being the most extensively studied.
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技术参数
- 靶点基因名
- ITGB1
- 基因别名
- FNRB; MDF2; MSK12
- 蛋白别名
- integrin subunit beta 1; ITGB1
- UniProt
- P05556
- 物种
- Human
产品详情
- 靶点名称
- ITGB1
- 蛋白名称
- integrin subunit beta 1
- 蛋白别名
- Integrin beta-1; Fibronectin receptor subunit beta; Glycoprotein IIa; GPIIA; VLA-4 subunit beta; CD antigen CD29
- 靶点基因名
- ITGB1
- 基因别名
- FNRB; MDF2; MSK12
- UniProt
- P05556
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Integrin subunit beta 1 (ITGB1) is a vital component of the integrin family, functioning as a transmembrane glycoprotein that forms heterodimers with various alpha subunits, facilitating crucial cellular processes such as adhesion, migration, and signaling. ITGB1 plays a significant role in numerous physiological functions, including embryogenesis and tissue repair, and is implicated in the pathogenesis of several diseases, notably cancers like gallbladder and breast cancer. Dysregulation of ITGB1 has been linked to tumor progression and metastasis, making it a potential prognostic biomarker and therapeutic target. The gene encoding ITGB1 is located on chromosome 10p11.22 and produces multiple isoforms, with the β1-A isoform being the most extensively studied.