人 ITGA11 抗体对
01AB01740
Integrin subunit alpha 11 (ITGA11) is a protein encoded by the ITGA11 gene and functions as an alpha integrin, forming a heterodimer with beta 1 integrin to create the α11β1 complex. This complex contains an I domain and acts as a critical collagen receptor, primarily expressed by stromal fibroblasts, mesenchymal stem cells, and muscle tissue, facilitating cell adhesion to the extracellular matrix and playing a role in osteogenic responses through high-affinity binding to Osteolectin. ITGA11 is expressed in various tissues, including bone marrow, skeletal muscle, and connective tissues, and its deficiency in mice leads to growth retardation and bone abnormalities. Disease associations include increased ITGA11 expression in fibrotic conditions such as liver cirrhosis, renal fibrosis, and lung fibrosis, as well as upregulation in the tumor stroma of pancreatic ductal adenocarcinoma, where it influences myofibroblast differentiation and tumor cell behavior.
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技术参数
- 靶点基因名
- ITGA11
- 蛋白别名
- integrin subunit alpha 11; ITGA11
- UniProt
- Q9UKX5
- 物种
- Human
产品详情
- 靶点名称
- ITGA11
- 蛋白名称
- integrin subunit alpha 11
- 蛋白别名
- Integrin alpha-11
- 靶点基因名
- ITGA11
- UniProt
- Q9UKX5
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Integrin subunit alpha 11 (ITGA11) is a protein encoded by the ITGA11 gene and functions as an alpha integrin, forming a heterodimer with beta 1 integrin to create the α11β1 complex. This complex contains an I domain and acts as a critical collagen receptor, primarily expressed by stromal fibroblasts, mesenchymal stem cells, and muscle tissue, facilitating cell adhesion to the extracellular matrix and playing a role in osteogenic responses through high-affinity binding to Osteolectin. ITGA11 is expressed in various tissues, including bone marrow, skeletal muscle, and connective tissues, and its deficiency in mice leads to growth retardation and bone abnormalities. Disease associations include increased ITGA11 expression in fibrotic conditions such as liver cirrhosis, renal fibrosis, and lung fibrosis, as well as upregulation in the tumor stroma of pancreatic ductal adenocarcinoma, where it influences myofibroblast differentiation and tumor cell behavior.