人 IRAKM 抗体对
01AB00529
Interleukin 1 receptor associated kinase 3 (IRAK3), also known as IRAK-M, is a pseudokinase that plays a critical role in modulating inflammation and immune responses. It is primarily expressed in monocytes and macrophages and is involved in the regulation of Toll-like receptor (TLR) signaling pathways. IRAK3 inhibits the dissociation of IRAK1 or IRAK2 from myddosome complexes, thereby downregulating NF-κB activation and reducing the production of inflammatory cytokines such as TNF-α and IL-6. IRAK3 is associated with endotoxin tolerance and sepsis, where its upregulation is linked to immunosuppression and worse clinical outcomes. Studies have shown that IRAK3 deficiency leads to enhanced sensitivity to TLR agonists and increased production of proinflammatory cytokines, highlighting its role as a negative regulator of inflammation.
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技术参数
- 靶点基因名
- IRAK3
- 蛋白别名
- interleukin 1 receptor associated kinase 3; IRAKM
- UniProt
- Q9Y616
- 物种
- Human
产品详情
- 靶点名称
- IRAKM
- 蛋白名称
- interleukin 1 receptor associated kinase 3
- 蛋白别名
- Interleukin-1 receptor-associated kinase 3; IRAK-3; IL-1 receptor-associated kinase M; IRAK-M; Inactive IL-1 receptor-associated kinase 3
- 靶点基因名
- IRAK3
- UniProt
- Q9Y616
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Interleukin 1 receptor associated kinase 3 (IRAK3), also known as IRAK-M, is a pseudokinase that plays a critical role in modulating inflammation and immune responses. It is primarily expressed in monocytes and macrophages and is involved in the regulation of Toll-like receptor (TLR) signaling pathways. IRAK3 inhibits the dissociation of IRAK1 or IRAK2 from myddosome complexes, thereby downregulating NF-κB activation and reducing the production of inflammatory cytokines such as TNF-α and IL-6. IRAK3 is associated with endotoxin tolerance and sepsis, where its upregulation is linked to immunosuppression and worse clinical outcomes. Studies have shown that IRAK3 deficiency leads to enhanced sensitivity to TLR agonists and increased production of proinflammatory cytokines, highlighting its role as a negative regulator of inflammation.