人 IRAG2 抗体对
01AB03222
Inositol 1,4,5-triphosphate receptor associated 2 (IRAG2), also known as Jaw1 or lymphoid-restricted membrane protein (LRMP), is a type II membrane protein that plays a crucial role in intracellular calcium signaling. It is primarily localized to the endoplasmic reticulum and interacts with inositol 1,4,5-triphosphate receptors (IP3Rs), modulating calcium release from intracellular stores. IRAG2 is expressed in various tissues, including immune cells and the pancreas, where it influences processes such as platelet aggregation and exocrine pancreatic function. Dysregulation of IRAG2 has been implicated in several diseases, particularly in cancer and immune disorders. For instance, altered expression of IRAG2 may affect immune cell function and contribute to autoimmune diseases. In cancer, its role as a modulator of calcium signaling suggests that changes in IRAG2 expression could influence tumor growth and metastasis.
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技术参数
- 靶点基因名
- IRAG2
- 基因别名
- JAW1; LRMP
- 蛋白别名
- inositol 1,4,5-triphosphate receptor associated 2; IRAG2
- UniProt
- Q12912
- 物种
- Human
产品详情
- 靶点名称
- IRAG2
- 蛋白名称
- inositol 1,4,5-triphosphate receptor associated 2
- 蛋白别名
- Inositol 1; 4; 5-triphosphate receptor associated 2; Lymphoid-restricted membrane protein; Protein Jaw1) [Cleaved into: Processed inositol 1; 4; 5-triphosphate receptor associated 2]
- 靶点基因名
- IRAG2
- 基因别名
- JAW1; LRMP
- UniProt
- Q12912
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Inositol 1,4,5-triphosphate receptor associated 2 (IRAG2), also known as Jaw1 or lymphoid-restricted membrane protein (LRMP), is a type II membrane protein that plays a crucial role in intracellular calcium signaling. It is primarily localized to the endoplasmic reticulum and interacts with inositol 1,4,5-triphosphate receptors (IP3Rs), modulating calcium release from intracellular stores. IRAG2 is expressed in various tissues, including immune cells and the pancreas, where it influences processes such as platelet aggregation and exocrine pancreatic function. Dysregulation of IRAG2 has been implicated in several diseases, particularly in cancer and immune disorders. For instance, altered expression of IRAG2 may affect immune cell function and contribute to autoimmune diseases. In cancer, its role as a modulator of calcium signaling suggests that changes in IRAG2 expression could influence tumor growth and metastasis.