人 IQGAP2 抗体对
01AB03209
Ras GTPase-activating-like protein IQGAP2 (IQGAP2) is a multifunctional scaffold protein encoded by the IQGAP2 gene, which is primarily expressed in the liver and other tissues. It plays a critical role in regulating cellular processes such as cytoskeletal dynamics, cell adhesion, and signal transduction through interactions with various proteins, including GTPases like CDC42 and RAC1. IQGAP2 contains multiple functional domains, including IQ motifs, a calponin homology domain, and a Ras-GAP domain, which facilitate its involvement in cell morphology and motility. IQGAP2 has been identified as a tumor suppressor in several cancers; its reduced expression is associated with increased epithelial-mesenchymal transition (EMT) and enhanced metastatic potential in breast cancer.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 靶点基因名
- IQGAP2
- 蛋白别名
- IQ motif containing GTPase activating protein 2; IQGAP2
- UniProt
- Q13576
- 物种
- Human
产品详情
- 靶点名称
- IQGAP2
- 蛋白名称
- IQ motif containing GTPase activating protein 2
- 蛋白别名
- Ras GTPase-activating-like protein IQGAP2
- 靶点基因名
- IQGAP2
- UniProt
- Q13576
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Ras GTPase-activating-like protein IQGAP2 (IQGAP2) is a multifunctional scaffold protein encoded by the IQGAP2 gene, which is primarily expressed in the liver and other tissues. It plays a critical role in regulating cellular processes such as cytoskeletal dynamics, cell adhesion, and signal transduction through interactions with various proteins, including GTPases like CDC42 and RAC1. IQGAP2 contains multiple functional domains, including IQ motifs, a calponin homology domain, and a Ras-GAP domain, which facilitate its involvement in cell morphology and motility. IQGAP2 has been identified as a tumor suppressor in several cancers; its reduced expression is associated with increased epithelial-mesenchymal transition (EMT) and enhanced metastatic potential in breast cancer.