人 IQGAP1 抗体对
01AB02481
IQ motif containing GTPase activating protein 1 (IQGAP1) is a large cytoplasmic scaffold protein that integrates multiple signaling pathways to regulate actin cytoskeleton organization, cell adhesion, and polarity. Despite its homology to Ras GTPase-activating proteins, IQGAP1 does not stimulate GTP hydrolysis; instead, it binds and stabilizes the active, GTP-bound forms of Cdc42 and Rac1. Through its diverse domains, it interacts with a wide array of partners, including F-actin, E-cadherin, β-catenin, and components of the MAPK signaling cascade such as B-Raf and ERK1/2. These interactions allow IQGAP1 to coordinate cytoskeletal remodeling with cell-cycle progression and migration. Pathologically, IQGAP1 is frequently overexpressed in various cancers, where it drives oncogenic signaling, invasion, and metastasis, making it a significant target for therapeutic intervention.
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技术参数
- 靶点基因名
- IQGAP1
- 基因别名
- KIAA0051
- 蛋白别名
- IQ motif containing GTPase activating protein 1; IQGAP1
- UniProt
- P46940
- 物种
- Human
产品详情
- 靶点名称
- IQGAP1
- 蛋白名称
- IQ motif containing GTPase activating protein 1
- 蛋白别名
- Ras GTPase-activating-like protein IQGAP1; p195
- 靶点基因名
- IQGAP1
- 基因别名
- KIAA0051
- UniProt
- P46940
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
IQ motif containing GTPase activating protein 1 (IQGAP1) is a large cytoplasmic scaffold protein that integrates multiple signaling pathways to regulate actin cytoskeleton organization, cell adhesion, and polarity. Despite its homology to Ras GTPase-activating proteins, IQGAP1 does not stimulate GTP hydrolysis; instead, it binds and stabilizes the active, GTP-bound forms of Cdc42 and Rac1. Through its diverse domains, it interacts with a wide array of partners, including F-actin, E-cadherin, β-catenin, and components of the MAPK signaling cascade such as B-Raf and ERK1/2. These interactions allow IQGAP1 to coordinate cytoskeletal remodeling with cell-cycle progression and migration. Pathologically, IQGAP1 is frequently overexpressed in various cancers, where it drives oncogenic signaling, invasion, and metastasis, making it a significant target for therapeutic intervention.