抗人 IP3 Receptor 抗体对
01AB02421
Inositol 1,4,5-trisphosphate receptor type 1 (IP3 Receptor) is a large tetrameric intracellular calcium release channel primarily localized to the endoplasmic reticulum membrane. Each subunit contains a cytosolic N-terminal IP3-binding core and a C-terminal six-transmembrane channel domain that forms a calcium-selective pore. The receptor is activated by the binding of IP3, produced downstream of G-protein-coupled receptor signaling, which primes the channel for calcium-induced calcium release. This mechanism regulates critical cellular processes including synaptic plasticity, gene expression, and apoptosis. IP3 Receptor is highly expressed in cerebellar Purkinje cells and is essential for motor coordination. Pathogenic variants in the ITPR1 gene cause autosomal dominant spinocerebellar ataxias and Gillespie syndrome, characterized by cerebellar atrophy, ataxia, and developmental delay.
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技术参数
- 靶点基因名
- ITPR1
- 基因别名
- INSP3R1
- 蛋白别名
- inositol 1,4,5-trisphosphate receptor type 1; IP3 Receptor
- UniProt
- Q14643
- 物种
- Human
产品详情
- 靶点名称
- IP3 Receptor
- 蛋白名称
- inositol 1,4,5-trisphosphate receptor type 1
- 蛋白别名
- Inositol 1; 4; 5-trisphosphate-gated calcium channel ITPR1; IP3 receptor isoform 1; IP3R 1; InsP3R1; Inositol 1; 4; 5 trisphosphate receptor; Inositol 1; 4; 5-trisphosphate receptor type 1; Type 1 inositol 1; 4; 5-trisphosphate receptor; Type 1 InsP3 receptor
- 靶点基因名
- ITPR1
- 基因别名
- INSP3R1
- UniProt
- Q14643
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Inositol 1,4,5-trisphosphate receptor type 1 (IP3 Receptor) is a large tetrameric intracellular calcium release channel primarily localized to the endoplasmic reticulum membrane. Each subunit contains a cytosolic N-terminal IP3-binding core and a C-terminal six-transmembrane channel domain that forms a calcium-selective pore. The receptor is activated by the binding of IP3, produced downstream of G-protein-coupled receptor signaling, which primes the channel for calcium-induced calcium release. This mechanism regulates critical cellular processes including synaptic plasticity, gene expression, and apoptosis. IP3 Receptor is highly expressed in cerebellar Purkinje cells and is essential for motor coordination. Pathogenic variants in the ITPR1 gene cause autosomal dominant spinocerebellar ataxias and Gillespie syndrome, characterized by cerebellar atrophy, ataxia, and developmental delay.