人 IP10 抗体对
01AB00203
C-X-C motif chemokine ligand 10 (CXCL10) is an 8.7 kDa protein encoded by the CXCL10 gene. It belongs to the CXC chemokine family and is secreted by various cell types, including monocytes, endothelial cells, and fibroblasts, in response to IFN-γ. CXCL10 plays multiple roles, such as chemoattracting monocytes/macrophages, T cells, NK cells, and dendritic cells, promoting T cell adhesion to endothelial cells, and exhibiting antitumor activity and inhibition of angiogenesis. It elicits its effects by binding to the chemokine receptor CXCR3. Elevated baseline pre-treatment plasma levels of CXCL10 are associated with poor response to antiviral therapy in patients with hepatitis C virus (HCV) infection, and it has been identified as a biomarker for heart failure and left ventricular dysfunction. Additionally, CXCL10 is involved in host defense mechanisms against certain intracellular pathogens like Leishmania major.
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技术参数
- 靶点基因名
- CXCL10
- 基因别名
- INP10; SCYB10
- 蛋白别名
- C-X-C motif chemokine ligand 10; IP10
- UniProt
- P02778
- 物种
- Human
产品详情
- 靶点名称
- IP10
- 蛋白名称
- C-X-C motif chemokine ligand 10
- 蛋白别名
- C-X-C motif chemokine 10; 10 kDa interferon gamma-induced protein; Gamma-IP10; IP-10; Small-inducible cytokine B10) [Cleaved into: CXCL10(1-73]
- 靶点基因名
- CXCL10
- 基因别名
- INP10; SCYB10
- UniProt
- P02778
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
C-X-C motif chemokine ligand 10 (CXCL10) is an 8.7 kDa protein encoded by the CXCL10 gene. It belongs to the CXC chemokine family and is secreted by various cell types, including monocytes, endothelial cells, and fibroblasts, in response to IFN-γ. CXCL10 plays multiple roles, such as chemoattracting monocytes/macrophages, T cells, NK cells, and dendritic cells, promoting T cell adhesion to endothelial cells, and exhibiting antitumor activity and inhibition of angiogenesis. It elicits its effects by binding to the chemokine receptor CXCR3. Elevated baseline pre-treatment plasma levels of CXCL10 are associated with poor response to antiviral therapy in patients with hepatitis C virus (HCV) infection, and it has been identified as a biomarker for heart failure and left ventricular dysfunction. Additionally, CXCL10 is involved in host defense mechanisms against certain intracellular pathogens like Leishmania major.