人肠碱性磷酸酶抗体对
01AB01428
Alkaline phosphatase, intestinal (ALPI), is an endogenous enzyme encoded by the ALPI gene and primarily expressed in the small intestine, where it plays a crucial role in maintaining gut homeostasis. This enzyme exhibits alkaline phosphatase activity, hydrolyzing phosphate groups from various molecules, and is involved in detoxifying bacterial toxins, dephosphorylating phosphorylated nucleotides, and regulating lipid absorption. ALPI also influences the intestinal microbiome and modulates both bicarbonate secretion and the pH of the duodenum, contributing to optimal digestive function and mucosal protection. On the disease side, ALPI is implicated in preventing increased intestinal permeability, which can be induced by certain bacteria, by inhibiting pathways that disrupt tight junctions, thereby protecting against gut barrier dysfunction and related inflammatory conditions.
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技术参数
- 靶点基因名
- ALPI
- 蛋白别名
- alkaline phosphatase, intestinal; Intestinal Alkaline Phosphatase
- UniProt
- P09923
- 物种
- Human
产品详情
- 靶点名称
- Intestinal Alkaline Phosphatase
- 蛋白名称
- alkaline phosphatase, intestinal
- 蛋白别名
- Intestinal-type alkaline phosphatase; IAP; Intestinal alkaline phosphatase
- 靶点基因名
- ALPI
- UniProt
- P09923
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Alkaline phosphatase, intestinal (ALPI), is an endogenous enzyme encoded by the ALPI gene and primarily expressed in the small intestine, where it plays a crucial role in maintaining gut homeostasis. This enzyme exhibits alkaline phosphatase activity, hydrolyzing phosphate groups from various molecules, and is involved in detoxifying bacterial toxins, dephosphorylating phosphorylated nucleotides, and regulating lipid absorption. ALPI also influences the intestinal microbiome and modulates both bicarbonate secretion and the pH of the duodenum, contributing to optimal digestive function and mucosal protection. On the disease side, ALPI is implicated in preventing increased intestinal permeability, which can be induced by certain bacteria, by inhibiting pathways that disrupt tight junctions, thereby protecting against gut barrier dysfunction and related inflammatory conditions.