抗人 Interferon gamma Receptor 1 抗体对
01AB00677
Interferon gamma receptor 1 (IFNGR1), also known as CD119, is a protein encoded by the IFNGR1 gene in humans. It is the ligand-binding chain (alpha) of the heterodimeric gamma interferon receptor, which is crucial for the signaling of interferon-gamma (IFN-γ). IFNGR1 interacts with IFN-γ and, together with IFNGR2, forms a receptor complex that activates the JAK/STAT signaling pathway, leading to antiviral, proapoptotic, and antiproliferation activities. Mutations in the IFNGR1 gene can lead to extreme susceptibility to mycobacterial infections, such as familial disseminated atypical mycobacterial infection, and are associated with susceptibility to Helicobacter pylori infection. The deregulation of IFNGR1 expression has also been implicated in the progression of lung adenocarcinoma, affecting IFN-γ signaling and antiviral responses.
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技术参数
- 靶点基因名
- IFNGR1
- 蛋白别名
- interferon gamma receptor 1; Interferon gamma Receptor 1
- UniProt
- P15260
- 物种
- Human
产品详情
- 靶点名称
- Interferon gamma Receptor 1
- 蛋白名称
- interferon gamma receptor 1
- 蛋白别名
- Interferon gamma receptor 1; IFN-gamma receptor 1; IFN-gamma-R1; CDw119; Interferon gamma receptor alpha-chain; IFN-gamma-R-alpha; CD antigen CD119
- 靶点基因名
- IFNGR1
- UniProt
- P15260
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Interferon gamma receptor 1 (IFNGR1), also known as CD119, is a protein encoded by the IFNGR1 gene in humans. It is the ligand-binding chain (alpha) of the heterodimeric gamma interferon receptor, which is crucial for the signaling of interferon-gamma (IFN-γ). IFNGR1 interacts with IFN-γ and, together with IFNGR2, forms a receptor complex that activates the JAK/STAT signaling pathway, leading to antiviral, proapoptotic, and antiproliferation activities. Mutations in the IFNGR1 gene can lead to extreme susceptibility to mycobacterial infections, such as familial disseminated atypical mycobacterial infection, and are associated with susceptibility to Helicobacter pylori infection. The deregulation of IFNGR1 expression has also been implicated in the progression of lung adenocarcinoma, affecting IFN-γ signaling and antiviral responses.