人 Interferon gamma 抗体对
01AB01792
IFNγ is a cytokine with important roles in immune and inflammatory responses, as well as tissue homeostasis and tumor immunosurveillance. It is a key mediator of inflammation in certain autoinflammatory diseases, such as hemophagocytic lymphohistiocytosis and macrophage activation syndrome, where high levels of IFNγ can activate macrophages. IFNγ also contributes to autoimmune responses by promoting the generation of T follicular helper cells, germinal centers, and pathogenic autoantibodies in systemic lupus erythematosus models. Additionally, IFNγ signaling has been implicated in the development of age-associated B cells, which accumulate prematurely and contribute to autoantibody production in SLE. While IFNγ can have protective effects in some autoinflammatory diseases, it is considered a potential therapeutic target in autoimmune disorders due to its pro-inflammatory roles. Overall, the complex and context-dependent functions of IFNγ highlight its importance in regulating immune responses and maintaining tissue homeostasis, as well as its potential as a therapeutic target in certain inflammatory and autoimmune conditions.
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技术参数
- 靶点基因名
- IFNG
- 蛋白别名
- interferon gamma; Interferon gamma
- UniProt
- P01579
- 物种
- Human
产品详情
- 靶点名称
- Interferon gamma
- 蛋白名称
- interferon gamma
- 蛋白别名
- Interferon gamma; IFN-gamma; Immune interferon
- 靶点基因名
- IFNG
- UniProt
- P01579
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
IFNγ is a cytokine with important roles in immune and inflammatory responses, as well as tissue homeostasis and tumor immunosurveillance. It is a key mediator of inflammation in certain autoinflammatory diseases, such as hemophagocytic lymphohistiocytosis and macrophage activation syndrome, where high levels of IFNγ can activate macrophages. IFNγ also contributes to autoimmune responses by promoting the generation of T follicular helper cells, germinal centers, and pathogenic autoantibodies in systemic lupus erythematosus models. Additionally, IFNγ signaling has been implicated in the development of age-associated B cells, which accumulate prematurely and contribute to autoantibody production in SLE. While IFNγ can have protective effects in some autoinflammatory diseases, it is considered a potential therapeutic target in autoimmune disorders due to its pro-inflammatory roles. Overall, the complex and context-dependent functions of IFNγ highlight its importance in regulating immune responses and maintaining tissue homeostasis, as well as its potential as a therapeutic target in certain inflammatory and autoimmune conditions.