人 Integrin beta-2 抗体对
01AB01744
Integrin subunit beta 2 (Integrin beta-2) is a transmembrane glycoprotein that serves as the common β chain for the leukocyte-specific integrins αLβ2 (LFA-1), αMβ2 (Mac-1), αXβ2, and αDβ2. These heterodimers are essential adhesion receptors that bind to ligands such as ICAM-1 and fibrinogen, mediating leukocyte adhesion, extravasation, and complement-driven phagocytosis during immune responses. The activity of β2 integrins is tightly regulated by conformational changes that couple the cytoplasmic tail to the actin cytoskeleton. Germline loss-of-function mutations in the ITGB2 gene cause leukocyte adhesion deficiency type I (LAD-I). This clinical condition is characterized by recurrent severe bacterial infections, impaired wound healing, and a lack of neutrophil extravasation, often requiring hematopoietic stem cell transplantation for survival.
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技术参数
- 靶点基因名
- ITGB2
- 基因别名
- CD18; MFI7
- 蛋白别名
- integrin subunit beta 2; Integrin beta-2
- UniProt
- P05107
- 物种
- Human
产品详情
- 靶点名称
- Integrin beta-2
- 蛋白名称
- integrin subunit beta 2
- 蛋白别名
- Integrin beta-2; Cell surface adhesion glycoproteins LFA-1/CR3/p150; 95 subunit beta; Complement receptor C3 subunit beta; CD antigen CD18
- 靶点基因名
- ITGB2
- 基因别名
- CD18; MFI7
- UniProt
- P05107
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Integrin subunit beta 2 (Integrin beta-2) is a transmembrane glycoprotein that serves as the common β chain for the leukocyte-specific integrins αLβ2 (LFA-1), αMβ2 (Mac-1), αXβ2, and αDβ2. These heterodimers are essential adhesion receptors that bind to ligands such as ICAM-1 and fibrinogen, mediating leukocyte adhesion, extravasation, and complement-driven phagocytosis during immune responses. The activity of β2 integrins is tightly regulated by conformational changes that couple the cytoplasmic tail to the actin cytoskeleton. Germline loss-of-function mutations in the ITGB2 gene cause leukocyte adhesion deficiency type I (LAD-I). This clinical condition is characterized by recurrent severe bacterial infections, impaired wound healing, and a lack of neutrophil extravasation, often requiring hematopoietic stem cell transplantation for survival.