抗人 Integrin alpha-V 抗体对
01AB02418
Integrin subunit alpha V (Integrin alpha-V) is a type I transmembrane glycoprotein that heterodimerizes with various beta subunits to form receptors for extracellular matrix ligands containing the RGD motif, such as vitronectin and fibronectin. These alpha-V-containing integrins are essential for cell adhesion, migration, and growth factor signaling. Specifically, alpha-V-beta-6 and alpha-V-beta-8 dimers facilitate the activation of latent TGF-beta-1, linking mechanical forces to profibrotic and immunoregulatory pathways. Integrin alpha-V is heavily implicated in tumor progression, invasion, and metastasis through its interactions with signaling molecules like FGF and IGF. Clinically, mutations in the ITGAV gene are associated with visceral myopathy 1. Furthermore, alpha-V integrins serve as cellular receptors for several viruses, including adenoviruses and coxsackieviruses, making them significant targets in oncology and infectious disease research.
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技术参数
- 靶点基因名
- ITGAV
- 基因别名
- MSK8; VNRA; VTNR
- 蛋白别名
- integrin subunit alpha V; Integrin alpha-V
- UniProt
- P06756
- 物种
- Human
产品详情
- 靶点名称
- Integrin alpha-V
- 蛋白名称
- integrin subunit alpha V
- 蛋白别名
- Integrin alpha-V; Vitronectin receptor; Vitronectin receptor subunit alpha; CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain; Integrin alpha-V light chain]
- 靶点基因名
- ITGAV
- 基因别名
- MSK8; VNRA; VTNR
- UniProt
- P06756
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Integrin subunit alpha V (Integrin alpha-V) is a type I transmembrane glycoprotein that heterodimerizes with various beta subunits to form receptors for extracellular matrix ligands containing the RGD motif, such as vitronectin and fibronectin. These alpha-V-containing integrins are essential for cell adhesion, migration, and growth factor signaling. Specifically, alpha-V-beta-6 and alpha-V-beta-8 dimers facilitate the activation of latent TGF-beta-1, linking mechanical forces to profibrotic and immunoregulatory pathways. Integrin alpha-V is heavily implicated in tumor progression, invasion, and metastasis through its interactions with signaling molecules like FGF and IGF. Clinically, mutations in the ITGAV gene are associated with visceral myopathy 1. Furthermore, alpha-V integrins serve as cellular receptors for several viruses, including adenoviruses and coxsackieviruses, making them significant targets in oncology and infectious disease research.