抗人整合素 alpha-L 抗体对
01AB01181
Integrin subunit alpha L (ITGAL), also known as CD11a or LFA-1 alpha, is a crucial component of the integrin family, forming the lymphocyte function-associated antigen-1 (LFA-1) heterodimer when paired with the beta-2 subunit (ITGB2). This transmembrane protein is expressed on all leukocytes and serves as a receptor for intercellular adhesion molecules (ICAMs 1-3), mediating essential functions in immune cell adhesion, migration, and costimulatory signaling at the immunological synapse. ITGAL’s role as a platform at the immunological synapse allows it to translate T cell receptor (TCR) engagement and ICAM1 density into graded adhesion responses, which are vital for effective immune surveillance and response. Dysfunction or altered expression of ITGAL has been implicated in immune-related diseases, as its central role in leukocyte adhesion and signaling can influence inflammatory and autoimmune conditions.
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技术参数
- 靶点基因名
- ITGAL
- 基因别名
- CD11A
- 蛋白别名
- integrin subunit alpha L; Integrin alpha-L
- UniProt
- P20701
- 物种
- Human
产品详情
- 靶点名称
- Integrin alpha-L
- 蛋白名称
- integrin subunit alpha L
- 蛋白别名
- Integrin alpha-L; CD11 antigen-like family member A; Leukocyte adhesion glycoprotein LFA-1 alpha chain; LFA-1A; Leukocyte function-associated molecule 1 alpha chain; CD antigen CD11a
- 靶点基因名
- ITGAL
- 基因别名
- CD11A
- UniProt
- P20701
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Integrin subunit alpha L (ITGAL), also known as CD11a or LFA-1 alpha, is a crucial component of the integrin family, forming the lymphocyte function-associated antigen-1 (LFA-1) heterodimer when paired with the beta-2 subunit (ITGB2). This transmembrane protein is expressed on all leukocytes and serves as a receptor for intercellular adhesion molecules (ICAMs 1-3), mediating essential functions in immune cell adhesion, migration, and costimulatory signaling at the immunological synapse. ITGAL’s role as a platform at the immunological synapse allows it to translate T cell receptor (TCR) engagement and ICAM1 density into graded adhesion responses, which are vital for effective immune surveillance and response. Dysfunction or altered expression of ITGAL has been implicated in immune-related diseases, as its central role in leukocyte adhesion and signaling can influence inflammatory and autoimmune conditions.