人 Integrin alpha-2 抗体对
01AB03244
Integrin alpha-2 (ITGA2) is a transmembrane protein that plays a vital role in cell adhesion and signaling by interacting with the extracellular matrix, primarily collagen. It is part of the integrin family and is crucial for various biological processes, including cell migration, proliferation, and differentiation. ITGA2 is expressed in several tissues, including platelets and various cancer types, where it influences tumor progression and metastasis. Dysregulation of ITGA2 has been implicated in multiple diseases, particularly cancers such as breast cancer, colorectal cancer, and gliomas. In breast cancer, for instance, high levels of ITGA2 expression are associated with increased tumor aggressiveness and poor patient prognosis. Moreover, alterations in ITGA2 expression can impact angiogenesis, further contributing to tumor development.
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技术参数
- 靶点基因名
- ITGA2
- 基因别名
- CD49B
- 蛋白别名
- integrin subunit alpha 2; Integrin alpha-2
- UniProt
- P17301
- 物种
- Human
产品详情
- 靶点名称
- Integrin alpha-2
- 蛋白名称
- integrin subunit alpha 2
- 蛋白别名
- Integrin alpha-2; CD49 antigen-like family member B; Collagen receptor; Platelet membrane glycoprotein Ia; GPIa; VLA-2 subunit alpha; CD antigen CD49b
- 靶点基因名
- ITGA2
- 基因别名
- CD49B
- UniProt
- P17301
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Integrin alpha-2 (ITGA2) is a transmembrane protein that plays a vital role in cell adhesion and signaling by interacting with the extracellular matrix, primarily collagen. It is part of the integrin family and is crucial for various biological processes, including cell migration, proliferation, and differentiation. ITGA2 is expressed in several tissues, including platelets and various cancer types, where it influences tumor progression and metastasis. Dysregulation of ITGA2 has been implicated in multiple diseases, particularly cancers such as breast cancer, colorectal cancer, and gliomas. In breast cancer, for instance, high levels of ITGA2 expression are associated with increased tumor aggressiveness and poor patient prognosis. Moreover, alterations in ITGA2 expression can impact angiogenesis, further contributing to tumor development.