人 INPP4B 抗体对
01AB03191
Inositol polyphosphate 4-phosphatase type II (INPP4B) is a dual specificity phosphatase that plays a significant role in phosphatidylinositol signaling pathways by dephosphorylating phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) to produce phosphatidylinositol 3-phosphate (PI(3)P). This enzymatic activity is crucial for regulating the PI3K/AKT signaling pathway, which is involved in cell growth, survival, and metabolism. INPP4B is recognized as a tumor suppressor, with its expression often reduced in various cancers, including breast, ovarian, and prostate cancers. Loss of INPP4B function can lead to enhanced activation of the PI3K/AKT pathway, promoting tumorigenesis and cancer progression. Additionally, studies have shown that INPP4B is downregulated in glioma tissues, where it inhibits cell proliferation and immune escape by modulating the PI3K/AKT pathway and reducing PD-L1 expression.
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技术参数
- 靶点基因名
- INPP4B
- 蛋白别名
- inositol polyphosphate-4-phosphatase type II B; INPP4B
- UniProt
- O15327
- 物种
- Human
产品详情
- 靶点名称
- INPP4B
- 蛋白名称
- inositol polyphosphate-4-phosphatase type II B
- 蛋白别名
- Inositol polyphosphate 4-phosphatase type II; Type II inositol 3; 4-bisphosphate 4-phosphatase
- 靶点基因名
- INPP4B
- UniProt
- O15327
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Inositol polyphosphate 4-phosphatase type II (INPP4B) is a dual specificity phosphatase that plays a significant role in phosphatidylinositol signaling pathways by dephosphorylating phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) to produce phosphatidylinositol 3-phosphate (PI(3)P). This enzymatic activity is crucial for regulating the PI3K/AKT signaling pathway, which is involved in cell growth, survival, and metabolism. INPP4B is recognized as a tumor suppressor, with its expression often reduced in various cancers, including breast, ovarian, and prostate cancers. Loss of INPP4B function can lead to enhanced activation of the PI3K/AKT pathway, promoting tumorigenesis and cancer progression. Additionally, studies have shown that INPP4B is downregulated in glioma tissues, where it inhibits cell proliferation and immune escape by modulating the PI3K/AKT pathway and reducing PD-L1 expression.