人 INPP1 抗体对
01AB02839
Inositol polyphosphate-1-phosphatase (INPP1) is a cytosolic, magnesium-dependent hydrolase that regulates phosphoinositide signaling by removing the 1-position phosphate from inositol polyphosphates. As a member of the lithium-sensitive phosphatase family, it plays a key role in intracellular calcium dynamics and second-messenger metabolism. Genetic studies have linked INPP1 to complex neuropsychiatric phenotypes, particularly bipolar disorder, highlighting its involvement in mood regulation pathways. Additionally, INPP1 dysfunction is associated with developmental anomalies such as ring dermoid of the cornea, underscoring its importance in both neuronal signaling and ocular development.
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技术参数
- 靶点基因名
- INPP1
- 蛋白别名
- inositol polyphosphate-1-phosphatase; INPP1
- UniProt
- P49441
- 物种
- Human
产品详情
- 靶点名称
- INPP1
- 蛋白名称
- inositol polyphosphate-1-phosphatase
- 蛋白别名
- Inositol polyphosphate 1-phosphatase; IPP; IPPase
- 靶点基因名
- INPP1
- UniProt
- P49441
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Inositol polyphosphate-1-phosphatase (INPP1) is a cytosolic, magnesium-dependent hydrolase that regulates phosphoinositide signaling by removing the 1-position phosphate from inositol polyphosphates. As a member of the lithium-sensitive phosphatase family, it plays a key role in intracellular calcium dynamics and second-messenger metabolism. Genetic studies have linked INPP1 to complex neuropsychiatric phenotypes, particularly bipolar disorder, highlighting its involvement in mood regulation pathways. Additionally, INPP1 dysfunction is associated with developmental anomalies such as ring dermoid of the cornea, underscoring its importance in both neuronal signaling and ocular development.