抗人 ING1 抗体对
01AB00681
Inhibitor of growth family member 1 (ING1) is a tumor suppressor protein that plays a crucial role in regulating cell growth, apoptosis, and senescence. It is encoded by the ING1 gene located on chromosome 13q34 and is characterized by its ability to induce cell growth arrest and apoptosis through interactions with the tumor suppressor protein TP53 and other proteins such as PCNA and HDAC1. ING1 has multiple isoforms, including ING1a and ING1b, which are widely expressed and particularly high in testes and thymus, respectively. Reduced expression and rearrangement of ING1 have been associated with various cancers, including head and neck squamous cell carcinoma, breast cancer, lung cancer, and gastric cancer. ING1's role in tumor suppression involves epigenetic regulation, affecting cancer hallmarks such as sustained cell proliferation and evasion of apoptosis.
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技术参数
- 靶点基因名
- ING1
- 蛋白别名
- inhibitor of growth family member 1; ING1
- UniProt
- Q9UK53
- 物种
- Human
产品详情
- 靶点名称
- ING1
- 蛋白名称
- inhibitor of growth family member 1
- 蛋白别名
- Inhibitor of growth protein 1
- 靶点基因名
- ING1
- UniProt
- Q9UK53
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Inhibitor of growth family member 1 (ING1) is a tumor suppressor protein that plays a crucial role in regulating cell growth, apoptosis, and senescence. It is encoded by the ING1 gene located on chromosome 13q34 and is characterized by its ability to induce cell growth arrest and apoptosis through interactions with the tumor suppressor protein TP53 and other proteins such as PCNA and HDAC1. ING1 has multiple isoforms, including ING1a and ING1b, which are widely expressed and particularly high in testes and thymus, respectively. Reduced expression and rearrangement of ING1 have been associated with various cancers, including head and neck squamous cell carcinoma, breast cancer, lung cancer, and gastric cancer. ING1's role in tumor suppression involves epigenetic regulation, affecting cancer hallmarks such as sustained cell proliferation and evasion of apoptosis.