抗人 IMPA1 抗体对
01AB01176
Inositol monophosphatase 1 (IMPA1) is an enzyme responsible for dephosphorylating myo-inositol monophosphate to generate free myo-inositol, which serves as a precursor for phosphatidylinositol synthesis. Located in the cytoplasm, IMPA1 plays a crucial role in maintaining normal brain function by providing inositol required for the synthesis of phosphatidylinositols and polyphosphoinositides. The enzyme is encoded by the IMPA1 gene in humans and is part of the essential phosphatidylinositol signaling pathway. In terms of disease associations, IMPA1 in promoting triple-negative breast cancer progression through its regulation of the mTOR pathway and epithelial-mesenchymal transition (EMT) process. Additionally, IMPA1 is a target of lithium, which inhibits the enzyme to induce autophagy, suggesting its potential involvement in mood disorders and other neuropsychiatric conditions for which lithium is prescribed.
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技术参数
- 靶点基因名
- IMPA1
- 基因别名
- IMPA
- 蛋白别名
- inositol monophosphatase 1; IMPA1
- UniProt
- P29218
- 物种
- Human
产品详情
- 靶点名称
- IMPA1
- 蛋白名称
- inositol monophosphatase 1
- 蛋白别名
- Inositol monophosphatase 1; IMP 1; IMPase 1; D-galactose 1-phosphate phosphatase; Inositol-1(or 4)-monophosphatase 1; Lithium-sensitive myo-inositol monophosphatase A1
- 靶点基因名
- IMPA1
- 基因别名
- IMPA
- UniProt
- P29218
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Inositol monophosphatase 1 (IMPA1) is an enzyme responsible for dephosphorylating myo-inositol monophosphate to generate free myo-inositol, which serves as a precursor for phosphatidylinositol synthesis. Located in the cytoplasm, IMPA1 plays a crucial role in maintaining normal brain function by providing inositol required for the synthesis of phosphatidylinositols and polyphosphoinositides. The enzyme is encoded by the IMPA1 gene in humans and is part of the essential phosphatidylinositol signaling pathway. In terms of disease associations, IMPA1 in promoting triple-negative breast cancer progression through its regulation of the mTOR pathway and epithelial-mesenchymal transition (EMT) process. Additionally, IMPA1 is a target of lithium, which inhibits the enzyme to induce autophagy, suggesting its potential involvement in mood disorders and other neuropsychiatric conditions for which lithium is prescribed.