人 IL8/CXCL8 抗体对
01AB01889
CXCL8, also known as interleukin-8 (IL-8), is a potent neutrophil-attracting and -activating chemokine that plays a crucial role in the inflammatory response. CXCL8 is involved in the recruitment and migration of various immune cells, particularly neutrophils, to sites of inflammation. This can lead to the development of different inflammatory diseases, such as airway, gastrointestinal, neurological, and autoimmune diseases like systemic lupus erythematosus. Elevated levels of CXCL8 have been found in inflamed tissues and the blood circulation in several inflammatory conditions. In addition, CXCL8 has been implicated in tumor biology, as it can promote cancer cell proliferation, survival, and angiogenesis in various types of cancer, including breast, prostate, lung, and colon cancer. Specific genetic polymorphisms in the CXCL8 gene have been associated with an increased risk or progression of certain cancers. Overall, the CXCL8-CXCR1/2 axis plays a significant role in both inflammatory diseases and cancer, making it an important target for clinical research and potential therapeutic interventions.
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技术参数
- 靶点基因名
- CXCL8
- 基因别名
- IL8
- 蛋白别名
- C-X-C motif chemokine ligand 8; IL8/CXCL8
- UniProt
- P10145
- 物种
- Human
产品详情
- 靶点名称
- IL8/CXCL8
- 蛋白名称
- C-X-C motif chemokine ligand 8
- 蛋白别名
- Interleukin-8; IL-8; C-X-C motif chemokine 8; Chemokine; C-X-C motif) ligand 8; Emoctakin; Granulocyte chemotactic protein 1; GCP-1; Monocyte-derived neutrophil chemotactic factor; MDNCF; Monocyte-derived neutrophil-activating peptide; MONAP; Neutrophil-activating protein 1; NAP-1; Protein 3-10C; T-cell chemotactic factor) [Cleaved into: MDNCF-a; GCP/IL-8 protein IV; IL8/NAP1 form I; Interleukin-8; (Ala-IL-8)77; GCP/IL-8 protein II; IL-8(1-77); IL8/NAP1 form II; MDNCF-b; IL-8(5-77; IL-8(6-77; (Ser-IL-8)72; GCP/IL-8 protein I; IL8/NAP1 form III; Lymphocyte-derived neutrophil-activating factor; LYNAP; MDNCF-c; Neutrophil-activating factor; NAF; IL-8(7-77; GCP/IL-8 protein V; IL8/NAP1 form IV; IL-8(8-77; GCP/IL-8 protein VI; IL8/NAP1 form V; IL-8(9-77; GCP/IL-8 protein III; IL8/NAP1 form VI]
- 靶点基因名
- CXCL8
- 基因别名
- IL8
- UniProt
- P10145
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
CXCL8, also known as interleukin-8 (IL-8), is a potent neutrophil-attracting and -activating chemokine that plays a crucial role in the inflammatory response. CXCL8 is involved in the recruitment and migration of various immune cells, particularly neutrophils, to sites of inflammation. This can lead to the development of different inflammatory diseases, such as airway, gastrointestinal, neurological, and autoimmune diseases like systemic lupus erythematosus. Elevated levels of CXCL8 have been found in inflamed tissues and the blood circulation in several inflammatory conditions. In addition, CXCL8 has been implicated in tumor biology, as it can promote cancer cell proliferation, survival, and angiogenesis in various types of cancer, including breast, prostate, lung, and colon cancer. Specific genetic polymorphisms in the CXCL8 gene have been associated with an increased risk or progression of certain cancers. Overall, the CXCL8-CXCR1/2 axis plays a significant role in both inflammatory diseases and cancer, making it an important target for clinical research and potential therapeutic interventions.