人 IL7 抗体对
01AB03775
Interleukin-7 (IL-7) is a hematopoietic cytokine primarily produced by stromal cells in the bone marrow and thymus. Signaling through the IL-7 receptor complex, it activates JAK-STAT and PI3K-Akt pathways to promote the survival, proliferation, and differentiation of B-cell and T-cell lineages. IL-7 is indispensable for thymopoiesis and the homeostatic maintenance of naive and memory T cells. Dysregulated IL-7 signaling is implicated in the pathogenesis of T-cell acute lymphoblastic leukemia and lymphoma. Clinically, recombinant IL-7 is utilized in immunotherapeutic strategies to enhance immune reconstitution in lymphopenic conditions.
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技术参数
- 靶点基因名
- IL7
- 蛋白别名
- interleukin 7; IL7
- UniProt
- P13232
- 物种
- Human
产品详情
- 靶点名称
- IL7
- 蛋白名称
- interleukin 7
- 蛋白别名
- Interleukin-7; IL-7
- 靶点基因名
- IL7
- UniProt
- P13232
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Interleukin-7 (IL-7) is a hematopoietic cytokine primarily produced by stromal cells in the bone marrow and thymus. Signaling through the IL-7 receptor complex, it activates JAK-STAT and PI3K-Akt pathways to promote the survival, proliferation, and differentiation of B-cell and T-cell lineages. IL-7 is indispensable for thymopoiesis and the homeostatic maintenance of naive and memory T cells. Dysregulated IL-7 signaling is implicated in the pathogenesis of T-cell acute lymphoblastic leukemia and lymphoma. Clinically, recombinant IL-7 is utilized in immunotherapeutic strategies to enhance immune reconstitution in lymphopenic conditions.