人 IL4 抗体对
01AB00279
Interleukin-4 (IL-4) is a multifunctional cytokine that plays a crucial role in regulating immune responses and inflammation. It is primarily produced by T helper 2 (Th2) cells, mast cells, eosinophils, and basophils. IL-4 has both pro-inflammatory and anti-inflammatory effects, depending on the context. In allergic diseases, IL-4 promotes inflammation by inducing IgE production, enhancing eosinophil recruitment, and stimulating mucus secretion. IL-4 exhibits anti-inflammatory properties by suppressing the production of pro-inflammatory cytokines like TNF-α and IL-1β in monocytes and macrophages. IL-4 also promotes the differentiation of naive T cells into Th2 cells, induces B cell class switching to IgE, and upregulates MHC class II production. In tissue repair and homeostasis, IL-4 drives the alternative activation of macrophages (M2 phenotype), which contribute to wound healing and resolution of inflammation. The complex interplay between IL-4's pro- and anti-inflammatory functions highlights its importance in maintaining immune balance and its potential as a therapeutic target in various inflammatory disorders.
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技术参数
- 靶点基因名
- IL4
- 蛋白别名
- interleukin 4; IL4
- UniProt
- P05112
- 物种
- Human
产品详情
- 靶点名称
- IL4
- 蛋白名称
- interleukin 4
- 蛋白别名
- Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra
- 靶点基因名
- IL4
- UniProt
- P05112
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Interleukin-4 (IL-4) is a multifunctional cytokine that plays a crucial role in regulating immune responses and inflammation. It is primarily produced by T helper 2 (Th2) cells, mast cells, eosinophils, and basophils. IL-4 has both pro-inflammatory and anti-inflammatory effects, depending on the context. In allergic diseases, IL-4 promotes inflammation by inducing IgE production, enhancing eosinophil recruitment, and stimulating mucus secretion. IL-4 exhibits anti-inflammatory properties by suppressing the production of pro-inflammatory cytokines like TNF-α and IL-1β in monocytes and macrophages. IL-4 also promotes the differentiation of naive T cells into Th2 cells, induces B cell class switching to IgE, and upregulates MHC class II production. In tissue repair and homeostasis, IL-4 drives the alternative activation of macrophages (M2 phenotype), which contribute to wound healing and resolution of inflammation. The complex interplay between IL-4's pro- and anti-inflammatory functions highlights its importance in maintaining immune balance and its potential as a therapeutic target in various inflammatory disorders.