人 IL37 抗体对
01AB02649
Interleukin-37 (IL-37) is an anti-inflammatory cytokine belonging to the IL-1 family, comprising five isoforms (IL-37a-e), with IL-37b being the most extensively studied. This protein plays a crucial role in modulating immune responses by inhibiting the production of pro-inflammatory cytokines, thereby protecting tissues from excessive inflammation and damage. Its mechanism involves binding to the IL-18 receptor and recruiting the co-receptor IL-1R8, which activates anti-inflammatory signaling pathways. Notably, IL-37 can also suppress the activation of the inflammasome, further contributing to its protective effects against inflammatory conditions. IL-37 is expressed in various tissues and its levels are notably elevated in inflammatory diseases such as systemic lupus erythematosus, colitis, asthma, and certain cancers.
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技术参数
- 靶点基因名
- IL37
- 基因别名
- FIL1Z; IL1F7; IL1H4; IL1RP1
- 蛋白别名
- interleukin 37; IL37
- UniProt
- Q9NZH6
- 物种
- Human
产品详情
- 靶点名称
- IL37
- 蛋白名称
- interleukin 37
- 蛋白别名
- Interleukin-37; IL-37; FIL1 zeta; IL-1X; Interleukin-1 family member 7; IL-1F7; Interleukin-1 homolog 4; IL-1H; IL-1H4; Interleukin-1 zeta; IL-1 zeta; Interleukin-1-related protein; IL-1RP1
- 靶点基因名
- IL37
- 基因别名
- FIL1Z; IL1F7; IL1H4; IL1RP1
- UniProt
- Q9NZH6
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Interleukin-37 (IL-37) is an anti-inflammatory cytokine belonging to the IL-1 family, comprising five isoforms (IL-37a-e), with IL-37b being the most extensively studied. This protein plays a crucial role in modulating immune responses by inhibiting the production of pro-inflammatory cytokines, thereby protecting tissues from excessive inflammation and damage. Its mechanism involves binding to the IL-18 receptor and recruiting the co-receptor IL-1R8, which activates anti-inflammatory signaling pathways. Notably, IL-37 can also suppress the activation of the inflammasome, further contributing to its protective effects against inflammatory conditions. IL-37 is expressed in various tissues and its levels are notably elevated in inflammatory diseases such as systemic lupus erythematosus, colitis, asthma, and certain cancers.