人 IL36B 抗体对
01AB00856
Interleukin 36 beta (IL-36β), also known as IL-1 family member 8 (IL1F8), is a cytokine belonging to the interleukin-1 superfamily. It is encoded by the IL36B gene located on chromosome 2, forming part of a cytokine gene cluster. Structurally, IL-36β contains a conserved 12-stranded β-trefoil fold similar to IL-1α and IL-1β, and exists in two splice variants encoding distinct isoforms. IL-36β acts as an agonist for the IL-36 receptor (IL-36R), activating downstream signaling pathways such as NF-κB and MAPK. These pathways promote pro-inflammatory responses, including the secretion of IL-6 and IL-8, and are involved in immune cell activation and antigen presentation. Predominantly expressed in epithelial tissues like skin and lungs, IL-36β plays a key role in regulating inflammation. Dysregulation of IL-36β has been implicated in inflammatory diseases such as psoriasis, rheumatoid arthritis, and inflammatory bowel disease. Its overactivation contributes to chronic inflammation and autoimmune pathologies.
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技术参数
- 靶点基因名
- IL36B
- 基因别名
- IL1F8; IL1H2
- 蛋白别名
- interleukin 36 beta; IL36B
- UniProt
- Q9NZH7
- 物种
- Human
产品详情
- 靶点名称
- IL36B
- 蛋白名称
- interleukin 36 beta
- 蛋白别名
- Interleukin-36 beta; FIL1 eta; Interleukin-1 eta; IL-1 eta; Interleukin-1 family member 8; IL-1F8; Interleukin-1 homolog 2; IL-1H2
- 靶点基因名
- IL36B
- 基因别名
- IL1F8; IL1H2
- UniProt
- Q9NZH7
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Interleukin 36 beta (IL-36β), also known as IL-1 family member 8 (IL1F8), is a cytokine belonging to the interleukin-1 superfamily. It is encoded by the IL36B gene located on chromosome 2, forming part of a cytokine gene cluster. Structurally, IL-36β contains a conserved 12-stranded β-trefoil fold similar to IL-1α and IL-1β, and exists in two splice variants encoding distinct isoforms. IL-36β acts as an agonist for the IL-36 receptor (IL-36R), activating downstream signaling pathways such as NF-κB and MAPK. These pathways promote pro-inflammatory responses, including the secretion of IL-6 and IL-8, and are involved in immune cell activation and antigen presentation. Predominantly expressed in epithelial tissues like skin and lungs, IL-36β plays a key role in regulating inflammation. Dysregulation of IL-36β has been implicated in inflammatory diseases such as psoriasis, rheumatoid arthritis, and inflammatory bowel disease. Its overactivation contributes to chronic inflammation and autoimmune pathologies.