人 IL33 抗体对
01AB01266
IL-33 is a member of the IL-1 cytokine family and is constitutively expressed in structural and lining cells, such as endothelial and epithelial cells. It acts as an "alarmin" that is released upon cell damage or necrosis to alert the immune system. IL-33 binds to the ST2 receptor, which is expressed on various immune cells including Th2 cells, mast cells, eosinophils, and group 2 innate lymphoid cells (ILC2s). This binding activates signaling pathways like NF-κB and MAPK that drive production of type 2 cytokines like IL-5 and IL-13. The IL-33/ST2 pathway plays a critical role in the pathogenesis of allergic and Th2-mediated diseases like asthma, atopic dermatitis, and anaphylaxis. Genetic studies have linked IL-33 and ST2 to increased susceptibility to asthma.
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技术参数
- 靶点基因名
- IL33
- 基因别名
- C9orf26; IL1F11; NFHEV
- 蛋白别名
- interleukin 33; IL33
- UniProt
- O95760
- 物种
- Human
产品详情
- 靶点名称
- IL33
- 蛋白名称
- interleukin 33
- 蛋白别名
- Interleukin-33; IL-33; Interleukin-1 family member 11; IL-1F11; Nuclear factor from high endothelial venules; NF-HEV) [Cleaved into: Interleukin-33; 95-270; Interleukin-33; 99-270; Interleukin-33; 109-270]
- 靶点基因名
- IL33
- 基因别名
- C9orf26; IL1F11; NFHEV
- UniProt
- O95760
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
IL-33 is a member of the IL-1 cytokine family and is constitutively expressed in structural and lining cells, such as endothelial and epithelial cells. It acts as an "alarmin" that is released upon cell damage or necrosis to alert the immune system. IL-33 binds to the ST2 receptor, which is expressed on various immune cells including Th2 cells, mast cells, eosinophils, and group 2 innate lymphoid cells (ILC2s). This binding activates signaling pathways like NF-κB and MAPK that drive production of type 2 cytokines like IL-5 and IL-13. The IL-33/ST2 pathway plays a critical role in the pathogenesis of allergic and Th2-mediated diseases like asthma, atopic dermatitis, and anaphylaxis. Genetic studies have linked IL-33 and ST2 to increased susceptibility to asthma.