抗人 IL32 抗体对
01AB02779
Interleukin-32 (IL-32) is a pro-inflammatory cytokine that plays a crucial role in immune regulation and inflammation. It exists in multiple isoforms generated by alternative splicing, with IL-32γ being the largest and most potent in inducing inflammatory responses. IL-32 lacks a typical signal peptide for secretion, but it can be released extracellularly, potentially through cell death or other mechanisms. The cytokine acts by inducing the production of other pro-inflammatory mediators, such as tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and IL-1β. Dysregulation of IL-32 has been linked to various inflammatory and autoimmune diseases, including rheumatoid arthritis and inflammatory bowel disease, where it contributes to disease pathogenesis by sustaining inflammation. Despite its pro-inflammatory role, IL-32 may also exhibit anti-inflammatory properties in certain contexts, as demonstrated in a murine model of allergic asthma.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 靶点基因名
- IL32
- 基因别名
- NK4; TAIF
- 蛋白别名
- interleukin 32; IL32
- UniProt
- P24001
- 物种
- Human
产品详情
- 靶点名称
- IL32
- 蛋白名称
- interleukin 32
- 蛋白别名
- Interleukin-32; IL-32; Natural killer cells protein 4; Tumor necrosis factor alpha-inducing factor
- 靶点基因名
- IL32
- 基因别名
- NK4; TAIF
- UniProt
- P24001
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Interleukin-32 (IL-32) is a pro-inflammatory cytokine that plays a crucial role in immune regulation and inflammation. It exists in multiple isoforms generated by alternative splicing, with IL-32γ being the largest and most potent in inducing inflammatory responses. IL-32 lacks a typical signal peptide for secretion, but it can be released extracellularly, potentially through cell death or other mechanisms. The cytokine acts by inducing the production of other pro-inflammatory mediators, such as tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and IL-1β. Dysregulation of IL-32 has been linked to various inflammatory and autoimmune diseases, including rheumatoid arthritis and inflammatory bowel disease, where it contributes to disease pathogenesis by sustaining inflammation. Despite its pro-inflammatory role, IL-32 may also exhibit anti-inflammatory properties in certain contexts, as demonstrated in a murine model of allergic asthma.