人 IL31 抗体对
01AB04062
Interleukin 31 (IL31) is a proinflammatory cytokine primarily produced by activated CD4+ T cells, particularly Th2 cells. It belongs to the gp130/IL-6 cytokine family but uniquely does not utilize the gp130 receptor. Instead, IL-31 signals through a heterodimeric receptor complex composed of IL-31 receptor A (IL31RA) and oncostatin M receptor (OSMR), activating multiple intracellular pathways, including JAK/STAT, MAPK, and PI3K/AKT. These signaling cascades are involved in various physiological responses, such as immune regulation and inflammation. IL-31 is implicated in several diseases, notably allergic conditions like atopic dermatitis and allergic contact dermatitis, as well as in cardiovascular issues such as Kawasaki disease and dilated cardiomyopathy.
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技术参数
- 靶点基因名
- IL31
- 蛋白别名
- interleukin 31; IL31
- UniProt
- Q6EBC2
- 物种
- Human
产品详情
- 靶点名称
- IL31
- 蛋白名称
- interleukin 31
- 蛋白别名
- Interleukin-31; IL-31
- 靶点基因名
- IL31
- UniProt
- Q6EBC2
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Interleukin 31 (IL31) is a proinflammatory cytokine primarily produced by activated CD4+ T cells, particularly Th2 cells. It belongs to the gp130/IL-6 cytokine family but uniquely does not utilize the gp130 receptor. Instead, IL-31 signals through a heterodimeric receptor complex composed of IL-31 receptor A (IL31RA) and oncostatin M receptor (OSMR), activating multiple intracellular pathways, including JAK/STAT, MAPK, and PI3K/AKT. These signaling cascades are involved in various physiological responses, such as immune regulation and inflammation. IL-31 is implicated in several diseases, notably allergic conditions like atopic dermatitis and allergic contact dermatitis, as well as in cardiovascular issues such as Kawasaki disease and dilated cardiomyopathy.