人 IL3 抗体对
01AB02214
Interleukin-3 (IL-3) is a cytokine primarily produced by activated T cells, playing a pivotal role in the immune system by regulating the proliferation and differentiation of various blood cell types. It acts as a multi-lineage growth factor, stimulating hematopoietic stem cells to differentiate into myeloid progenitor cells and promoting the survival of monocyte/macrophage progenitors, which are crucial for immune responses against pathogens. IL-3 also influences the inflammatory response, and its dysregulation has been implicated in various diseases, including hematological malignancies and autoimmune disorders. The signaling pathways activated by IL-3, particularly through its receptor, involve the JAK2/STAT5 pathway, which is essential for gene expression regulation and cell survival. Understanding IL-3's functions and its relationship with disease can provide insights into potential therapeutic targets for immune-related conditions and cancers.
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技术参数
- 靶点基因名
- IL3
- 蛋白别名
- interleukin 3; IL3
- UniProt
- P08700
- 物种
- Human
产品详情
- 靶点名称
- IL3
- 蛋白名称
- interleukin 3
- 蛋白别名
- Interleukin-3; IL-3; Hematopoietic growth factor; Mast cell growth factor; MCGF; Multipotential colony-stimulating factor; P-cell-stimulating factor
- 靶点基因名
- IL3
- UniProt
- P08700
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Interleukin-3 (IL-3) is a cytokine primarily produced by activated T cells, playing a pivotal role in the immune system by regulating the proliferation and differentiation of various blood cell types. It acts as a multi-lineage growth factor, stimulating hematopoietic stem cells to differentiate into myeloid progenitor cells and promoting the survival of monocyte/macrophage progenitors, which are crucial for immune responses against pathogens. IL-3 also influences the inflammatory response, and its dysregulation has been implicated in various diseases, including hematological malignancies and autoimmune disorders. The signaling pathways activated by IL-3, particularly through its receptor, involve the JAK2/STAT5 pathway, which is essential for gene expression regulation and cell survival. Understanding IL-3's functions and its relationship with disease can provide insights into potential therapeutic targets for immune-related conditions and cancers.