人 IL2RB 抗体对
01AB00524
Interleukin 2 receptor subunit beta (IL2RB), also known as CD122, is a type I membrane protein that plays a crucial role in the immune system by forming part of the interleukin-2 (IL-2) receptor complex. The protein consists of 220 amino acids, has a molecular weight of approximately 25.5 kDa, and is glycosylated, which contributes to its functional properties. Its expression is primarily found in hematopoietic tissues, highlighting its importance in immune responses. It exists in three forms based on its binding affinity to IL-2: a low-affinity monomer (alpha subunit), an intermediate-affinity heterodimer (alpha/beta), and a high-affinity heterotrimer (alpha/beta/gamma), which are essential for T cell activation and proliferation. Dysregulation or mutations in IL2RB are associated with several diseases, including immunodeficiency disorders characterized by lymphoproliferation and autoimmunity, as well as ichthyosis.
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技术参数
- 靶点基因名
- IL2RB
- 基因别名
- IL15RB
- 蛋白别名
- interleukin 2 receptor subunit beta; IL2RB
- UniProt
- P14784
- 物种
- Human
产品详情
- 靶点名称
- IL2RB
- 蛋白名称
- interleukin 2 receptor subunit beta
- 蛋白别名
- Interleukin-2 receptor subunit beta; IL-2 receptor subunit beta; IL-2R subunit beta; IL-2RB; High affinity IL-2 receptor subunit beta; Interleukin-15 receptor subunit beta; p70-75; p75; CD antigen CD122
- 靶点基因名
- IL2RB
- 基因别名
- IL15RB
- UniProt
- P14784
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Interleukin 2 receptor subunit beta (IL2RB), also known as CD122, is a type I membrane protein that plays a crucial role in the immune system by forming part of the interleukin-2 (IL-2) receptor complex. The protein consists of 220 amino acids, has a molecular weight of approximately 25.5 kDa, and is glycosylated, which contributes to its functional properties. Its expression is primarily found in hematopoietic tissues, highlighting its importance in immune responses. It exists in three forms based on its binding affinity to IL-2: a low-affinity monomer (alpha subunit), an intermediate-affinity heterodimer (alpha/beta), and a high-affinity heterotrimer (alpha/beta/gamma), which are essential for T cell activation and proliferation. Dysregulation or mutations in IL2RB are associated with several diseases, including immunodeficiency disorders characterized by lymphoproliferation and autoimmunity, as well as ichthyosis.