人 IL21R 抗体对
01AB00855
Interleukin-21 receptor (IL21R) is a type I cytokine receptor involved in immune regulation and is encoded by the human IL21R gene. It forms a heterodimeric complex with the common gamma chain (γc), shared by other cytokine receptors such as IL2R and IL15R, to mediate signaling. IL21R plays a critical role in the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells, activating key pathways like JAK1, JAK3, STAT1, and STAT3. Knockout studies in mice suggest its importance in immunoglobulin production Dysregulation of IL21R is implicated in diseases such as autoimmune disorders, chronic viral infections, and parasitic diseases. For example, mutations in IL21R can lead to primary immunodeficiency, characterized by recurrent infections and impaired adaptive immunity. Additionally, IL21R expression promotes breast cancer cell migration and invasion by enhancing matrix metalloproteinase signaling, highlighting its role in cancer progression.
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技术参数
- 靶点基因名
- IL21R
- 基因别名
- NILR
- 蛋白别名
- interleukin 21 receptor; IL21R
- UniProt
- Q9HBE5
- 物种
- Human
产品详情
- 靶点名称
- IL21R
- 蛋白名称
- interleukin 21 receptor
- 蛋白别名
- Interleukin-21 receptor; IL-21 receptor; IL-21R; Novel interleukin receptor; CD antigen CD360
- 靶点基因名
- IL21R
- 基因别名
- NILR
- UniProt
- Q9HBE5
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Interleukin-21 receptor (IL21R) is a type I cytokine receptor involved in immune regulation and is encoded by the human IL21R gene. It forms a heterodimeric complex with the common gamma chain (γc), shared by other cytokine receptors such as IL2R and IL15R, to mediate signaling. IL21R plays a critical role in the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells, activating key pathways like JAK1, JAK3, STAT1, and STAT3. Knockout studies in mice suggest its importance in immunoglobulin production Dysregulation of IL21R is implicated in diseases such as autoimmune disorders, chronic viral infections, and parasitic diseases. For example, mutations in IL21R can lead to primary immunodeficiency, characterized by recurrent infections and impaired adaptive immunity. Additionally, IL21R expression promotes breast cancer cell migration and invasion by enhancing matrix metalloproteinase signaling, highlighting its role in cancer progression.