人 IL18 抗体对
01AB01773
Interleukin-18 (IL-18) is a pro-inflammatory cytokine that plays a crucial role in various inflammatory and autoimmune diseases. IL-18 is involved in the regulation of both Th1 and Th2 immune responses, and its activity is balanced by the presence of IL-18 binding protein (IL-18BP). Elevated levels of IL-18 have been associated with several autoimmune and inflammatory conditions, including rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease, and macrophage activation syndrome. In these diseases, an imbalance between IL-18 and IL-18BP can lead to increased levels of free IL-18, which is more important for determining disease severity. IL-18 has also been implicated in heart disease, acute kidney injury, and neurological disorders such as cognitive impairment and agitation in severe mental illness.
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技术参数
- 靶点基因名
- IL18
- 基因别名
- IGIF; IL1F4
- 蛋白别名
- interleukin 18; IL18
- UniProt
- Q14116
- 物种
- Human
产品详情
- 靶点名称
- IL18
- 蛋白名称
- interleukin 18
- 蛋白别名
- Interleukin-18; IL-18; Iboctadekin; Interferon gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma; IL-1 gamma
- 靶点基因名
- IL18
- 基因别名
- IGIF; IL1F4
- UniProt
- Q14116
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Interleukin-18 (IL-18) is a pro-inflammatory cytokine that plays a crucial role in various inflammatory and autoimmune diseases. IL-18 is involved in the regulation of both Th1 and Th2 immune responses, and its activity is balanced by the presence of IL-18 binding protein (IL-18BP). Elevated levels of IL-18 have been associated with several autoimmune and inflammatory conditions, including rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease, and macrophage activation syndrome. In these diseases, an imbalance between IL-18 and IL-18BP can lead to increased levels of free IL-18, which is more important for determining disease severity. IL-18 has also been implicated in heart disease, acute kidney injury, and neurological disorders such as cognitive impairment and agitation in severe mental illness.