人 IL-16 抗体对
01AB00140
IL-16 is encoded by the IL16 gene located on chromosome 15q26.3. It is initially produced as a precursor protein (pro-IL-16) that is cleaved by caspase-3 to generate the mature, secreted form of IL-16. Both pro-IL-16 and mature IL-16 are biologically active. IL-16 functions as a chemoattractant for CD4+ T cells, monocytes, and eosinophils, and can also regulate cell growth and differentiation. Increased levels of IL-16 have been associated with various inflammatory and autoimmune diseases, including multiple sclerosis, rheumatoid arthritis, and antineutrophil cytoplasmic antibody-associated vasculitis. Genetic polymorphisms in the IL16 gene, such as rs11556218, have also been linked to an increased risk of certain cancers, as well as other conditions like diabetes and osteoarthritis. Overall, IL-16 appears to play a complex role in modulating immune and inflammatory responses, with implications for both disease pathogenesis and potential therapeutic targeting.
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技术参数
- 靶点基因名
- IL16
- 蛋白别名
- interleukin 16; IL16
- UniProt
- Q14005
- 物种
- Human
产品详情
- 靶点名称
- IL16
- 蛋白名称
- interleukin 16
- 蛋白别名
- Pro-interleukin-16 [Cleaved into: Interleukin-16; IL-16; Lymphocyte chemoattractant factor; LCF]
- 靶点基因名
- IL16
- UniProt
- Q14005
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
IL-16 is encoded by the IL16 gene located on chromosome 15q26.3. It is initially produced as a precursor protein (pro-IL-16) that is cleaved by caspase-3 to generate the mature, secreted form of IL-16. Both pro-IL-16 and mature IL-16 are biologically active. IL-16 functions as a chemoattractant for CD4+ T cells, monocytes, and eosinophils, and can also regulate cell growth and differentiation. Increased levels of IL-16 have been associated with various inflammatory and autoimmune diseases, including multiple sclerosis, rheumatoid arthritis, and antineutrophil cytoplasmic antibody-associated vasculitis. Genetic polymorphisms in the IL16 gene, such as rs11556218, have also been linked to an increased risk of certain cancers, as well as other conditions like diabetes and osteoarthritis. Overall, IL-16 appears to play a complex role in modulating immune and inflammatory responses, with implications for both disease pathogenesis and potential therapeutic targeting.