人 IL12B 抗体对
01AB00849
IL-12p40 is a cytokine that is a component of the bioactive cytokines interleukin (IL)-12 and IL-23, but recent research has shown that it also has intrinsic functional activity. IL-12p40 is induced in excess over the other subunits of IL-12 and IL-23 and can exist in a monomeric or homodimeric form. Its most widely appreciated function is to provide a negative feedback loop by competitively binding to the IL-12 receptor. However, IL-12p40 acts as a chemoattractant for macrophages and promotes the migration of bacterially stimulated dendritic cells. It is associated with several pathogenic inflammatory responses such as silicosis, graft rejection, and asthma, but it is also protective in a mycobacterial model.
| 规格 | 起售价 |
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技术参数
- 靶点基因名
- IL12B
- 基因别名
- NKSF2
- 蛋白别名
- interleukin 12B; IL12B
- UniProt
- P29460
- 物种
- Human
产品详情
- 靶点名称
- IL12B
- 蛋白名称
- interleukin 12B
- 蛋白别名
- Interleukin-12 subunit beta; IL-12B; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; IL-12 subunit p40; NK cell stimulatory factor chain 2; NKSF2
- 靶点基因名
- IL12B
- 基因别名
- NKSF2
- UniProt
- P29460
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
IL-12p40 is a cytokine that is a component of the bioactive cytokines interleukin (IL)-12 and IL-23, but recent research has shown that it also has intrinsic functional activity. IL-12p40 is induced in excess over the other subunits of IL-12 and IL-23 and can exist in a monomeric or homodimeric form. Its most widely appreciated function is to provide a negative feedback loop by competitively binding to the IL-12 receptor. However, IL-12p40 acts as a chemoattractant for macrophages and promotes the migration of bacterially stimulated dendritic cells. It is associated with several pathogenic inflammatory responses such as silicosis, graft rejection, and asthma, but it is also protective in a mycobacterial model.