人 IL-1 alpha 抗体对
01AB02924
Interleukin-1 alpha (IL-1α) is a key pro-inflammatory cytokine that plays a crucial role in various inflammatory diseases and cancer. It is constitutively expressed in epithelial, endothelial, and stromal cells, and its expression can be upregulated in both hematopoietic and non-hematopoietic cells by various danger- and pathogen-associated molecular patterns. IL-1α is unique in its ability to function as a membrane-bound molecule, translocate to the nucleus to modulate gene expression independently of its receptor, and be bioavailable in both pro-form and mature form during cell death. It has been implicated in the pathogenesis of autoinflammatory disorders, inflammatory bowel disease, cardiovascular diseases, and cancer progression, where it can promote inflammation, myeloid skewing, and tumor growth.
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技术参数
- 靶点基因名
- IL1A
- 基因别名
- IL1F1
- 蛋白别名
- interleukin 1 alpha; IL-1 alpha
- UniProt
- P01583
- 物种
- Human
产品详情
- 靶点名称
- IL-1 alpha
- 蛋白名称
- interleukin 1 alpha
- 蛋白别名
- Interleukin-1 alpha; IL-1 alpha; Hematopoietin-1
- 靶点基因名
- IL1A
- 基因别名
- IL1F1
- UniProt
- P01583
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Interleukin-1 alpha (IL-1α) is a key pro-inflammatory cytokine that plays a crucial role in various inflammatory diseases and cancer. It is constitutively expressed in epithelial, endothelial, and stromal cells, and its expression can be upregulated in both hematopoietic and non-hematopoietic cells by various danger- and pathogen-associated molecular patterns. IL-1α is unique in its ability to function as a membrane-bound molecule, translocate to the nucleus to modulate gene expression independently of its receptor, and be bioavailable in both pro-form and mature form during cell death. It has been implicated in the pathogenesis of autoinflammatory disorders, inflammatory bowel disease, cardiovascular diseases, and cancer progression, where it can promote inflammation, myeloid skewing, and tumor growth.