人 IGSF11 抗体对
01AB01723
Immunoglobulin superfamily member 11 (IGSF11) is a type I transmembrane glycoprotein that functions as a homophilic cell adhesion molecule and a stimulator of cell growth. Primarily expressed in the brain and testis, it acts as a cancer-testis antigen and is essential for the morphological differentiation and layer-specific organization of chandelier cell synapses in the nervous system. In oncogenic contexts, IGSF11 promotes cell migration and invasion by forming complexes with RAP1 and activating epithelial-mesenchymal transition programs. Clinically, IGSF11 is overexpressed in high-grade glioma, melanoma, and gastric cancer, where it contributes to tumor progression and serves as a potential therapeutic target.
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技术参数
- 靶点基因名
- IGSF11
- 基因别名
- BTIGSF; CXADRL1; VSIG3
- 蛋白别名
- immunoglobulin superfamily member 11; IGSF11
- UniProt
- Q5DX21
- 物种
- Human
产品详情
- 靶点名称
- IGSF11
- 蛋白名称
- immunoglobulin superfamily member 11
- 蛋白别名
- Immunoglobulin superfamily member 11; IgSF11; Brain and testis-specific immunoglobulin superfamily protein; Bt-IGSF; V-set and immunoglobulin domain-containing protein 3
- 靶点基因名
- IGSF11
- 基因别名
- BTIGSF; CXADRL1; VSIG3
- UniProt
- Q5DX21
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Immunoglobulin superfamily member 11 (IGSF11) is a type I transmembrane glycoprotein that functions as a homophilic cell adhesion molecule and a stimulator of cell growth. Primarily expressed in the brain and testis, it acts as a cancer-testis antigen and is essential for the morphological differentiation and layer-specific organization of chandelier cell synapses in the nervous system. In oncogenic contexts, IGSF11 promotes cell migration and invasion by forming complexes with RAP1 and activating epithelial-mesenchymal transition programs. Clinically, IGSF11 is overexpressed in high-grade glioma, melanoma, and gastric cancer, where it contributes to tumor progression and serves as a potential therapeutic target.