抗人 IGFBPL1 抗体对
01AB01500
Insulin like growth factor binding protein like 1 (IGFBPL1) is a secreted, cysteine-rich glycoprotein that belongs to the IGF-binding protein superfamily. It contains a conserved N-terminal domain that enables high-affinity binding to IGF-1, thereby modulating its bioavailability and downstream signaling. In the nervous system, IGFBPL1 acts as a co-factor that facilitates IGF-1-dependent PI3K/mTOR activation and intracellular calcium elevation, processes essential for retinal ganglion cell axon growth and regeneration. Clinically, IGFBPL1 is recognized as a neuroprotective factor in conditions such as optic nerve injury and glaucoma. Additionally, it plays a role in vascular health; it is often downregulated in unstable atherosclerotic plaques, where it normally functions to inhibit macrophage lipid accumulation via the IGF-1R/LXRalpha/ABCG1 signaling pathway.
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技术参数
- 靶点基因名
- IGFBPL1
- 基因别名
- IGFBPRP4
- 蛋白别名
- insulin like growth factor binding protein like 1; IGFBPL1
- UniProt
- Q8WX77
- 物种
- Human
产品详情
- 靶点名称
- IGFBPL1
- 蛋白名称
- insulin like growth factor binding protein like 1
- 蛋白别名
- Insulin-like growth factor-binding protein-like 1; IGFBP-related protein 10; Insulin-like growth factor-binding-related protein 4; IGFBP-rP4
- 靶点基因名
- IGFBPL1
- 基因别名
- IGFBPRP4
- UniProt
- Q8WX77
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Insulin like growth factor binding protein like 1 (IGFBPL1) is a secreted, cysteine-rich glycoprotein that belongs to the IGF-binding protein superfamily. It contains a conserved N-terminal domain that enables high-affinity binding to IGF-1, thereby modulating its bioavailability and downstream signaling. In the nervous system, IGFBPL1 acts as a co-factor that facilitates IGF-1-dependent PI3K/mTOR activation and intracellular calcium elevation, processes essential for retinal ganglion cell axon growth and regeneration. Clinically, IGFBPL1 is recognized as a neuroprotective factor in conditions such as optic nerve injury and glaucoma. Additionally, it plays a role in vascular health; it is often downregulated in unstable atherosclerotic plaques, where it normally functions to inhibit macrophage lipid accumulation via the IGF-1R/LXRalpha/ABCG1 signaling pathway.