人 IGFBP2 抗体对
01AB02368
IGFBP2 is a versatile molecule that plays a crucial role in various metabolic and cell cycle processes. Its molecular structure allows it to bind to IGFs (insulin-like growth factors) and act as a ligand through different domains within the protein. IGFBP2 is associated with metabolic disorders, including obesity, metabolic syndrome, and insulin resistance. Aberrant overexpression of IGFBP2 is linked to an aggressive phenotype in a broad range of human cancers, such as glioma, ovarian, prostate, pancreatic, and breast cancer. IGFBP2 performs IGF-independent roles in cancer development and progression through various molecular networks, including binding to integrins, extracellular matrix components, and important cell signaling regulatory molecules. Additionally, IGFBP2 is associated with tau-related pathology in Alzheimer's disease, as evidenced by its correlation with t-tau and p-tau levels in cerebrospinal fluid and its association with longitudinal rates of atrophy in AD-associated cortical regions.
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技术参数
- 靶点基因名
- IGFBP2
- 基因别名
- BP2; IBP2
- 蛋白别名
- insulin like growth factor binding protein 2; IGFBP2
- UniProt
- P18065
- 物种
- Human
产品详情
- 靶点名称
- IGFBP2
- 蛋白名称
- insulin like growth factor binding protein 2
- 蛋白别名
- Insulin-like growth factor-binding protein 2; IBP-2; IGF-binding protein 2; IGFBP-2
- 靶点基因名
- IGFBP2
- 基因别名
- BP2; IBP2
- UniProt
- P18065
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
IGFBP2 is a versatile molecule that plays a crucial role in various metabolic and cell cycle processes. Its molecular structure allows it to bind to IGFs (insulin-like growth factors) and act as a ligand through different domains within the protein. IGFBP2 is associated with metabolic disorders, including obesity, metabolic syndrome, and insulin resistance. Aberrant overexpression of IGFBP2 is linked to an aggressive phenotype in a broad range of human cancers, such as glioma, ovarian, prostate, pancreatic, and breast cancer. IGFBP2 performs IGF-independent roles in cancer development and progression through various molecular networks, including binding to integrins, extracellular matrix components, and important cell signaling regulatory molecules. Additionally, IGFBP2 is associated with tau-related pathology in Alzheimer's disease, as evidenced by its correlation with t-tau and p-tau levels in cerebrospinal fluid and its association with longitudinal rates of atrophy in AD-associated cortical regions.