抗人 IGF2R 抗体对
01AB01169
Insulin-like growth factor 2 receptor (IGF2R), also known as the cation-independent mannose-6-phosphate receptor, is a large, multifunctional transmembrane protein ubiquitously expressed in human tissues. Structurally, IGF2R is composed of a 300-kDa polypeptide with a substantial extracellular region containing 15 homologous domains, a single transmembrane segment, and a short cytoplasmic tail. Its primary functions include binding and internalizing insulin-like growth factor 2 (IGF2) to regulate its signaling, as well as trafficking lysosomal enzymes by recognizing mannose-6-phosphate tags and directing these enzymes from the Golgi apparatus to lysosomes. Specific domains within the extracellular region are responsible for binding IGF2 and phosphomannosyl residues, with domain 11 being critical for IGF2 binding and domains 3, 5, and 9 for mannose-6-phosphate recognition. Beyond its physiological roles, IGF2R is implicated in disease, serving as a prognostic marker in several cancers, such as cervical, kidney, and liver carcinomas, and its dysfunction can disrupt growth factor regulation and lysosomal enzyme trafficking.
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技术参数
- 靶点基因名
- IGF2R
- 基因别名
- MPRI
- 蛋白别名
- insulin like growth factor 2 receptor; IGF2R
- UniProt
- P11717
- 物种
- Human
产品详情
- 靶点名称
- IGF2R
- 蛋白名称
- insulin like growth factor 2 receptor
- 蛋白别名
- Cation-independent mannose-6-phosphate receptor; CI Man-6-P receptor; CI-MPR; M6PR; 300 kDa mannose 6-phosphate receptor; MPR 300; Insulin-like growth factor 2 receptor; Insulin-like growth factor II receptor; IGF-II receptor; M6P/IGF2 receptor; M6P/IGF2R; CD antigen CD222
- 靶点基因名
- IGF2R
- 基因别名
- MPRI
- UniProt
- P11717
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Insulin-like growth factor 2 receptor (IGF2R), also known as the cation-independent mannose-6-phosphate receptor, is a large, multifunctional transmembrane protein ubiquitously expressed in human tissues. Structurally, IGF2R is composed of a 300-kDa polypeptide with a substantial extracellular region containing 15 homologous domains, a single transmembrane segment, and a short cytoplasmic tail. Its primary functions include binding and internalizing insulin-like growth factor 2 (IGF2) to regulate its signaling, as well as trafficking lysosomal enzymes by recognizing mannose-6-phosphate tags and directing these enzymes from the Golgi apparatus to lysosomes. Specific domains within the extracellular region are responsible for binding IGF2 and phosphomannosyl residues, with domain 11 being critical for IGF2 binding and domains 3, 5, and 9 for mannose-6-phosphate recognition. Beyond its physiological roles, IGF2R is implicated in disease, serving as a prognostic marker in several cancers, such as cervical, kidney, and liver carcinomas, and its dysfunction can disrupt growth factor regulation and lysosomal enzyme trafficking.