抗人 IFNLR1 抗体对
01AB02983
Interferon lambda receptor 1 (IFNLR1), or IL28RA, is a type I transmembrane glycoprotein that pairs with IL10RB to form the functional receptor complex for type III interferons (IFN-λ). Predominantly expressed on epithelial cells, this receptor mediates antiviral and immunoregulatory signals through the JAK-STAT pathway, specifically activating STAT1 and STAT2. This restricted expression pattern allows IFNLR1 to orchestrate local immune responses at mucosal barriers without inducing systemic inflammation. Dysregulation of IFNLR1 signaling is associated with altered susceptibility to viral infections, such as hepatitis and Zika, and is implicated in inflammatory skin conditions like psoriasis.
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技术参数
- 靶点基因名
- IFNLR1
- 基因别名
- IL28RA; LICR2
- 蛋白别名
- interferon lambda receptor 1; IFNLR1
- UniProt
- Q8IU57
- 物种
- Human
产品详情
- 靶点名称
- IFNLR1
- 蛋白名称
- interferon lambda receptor 1
- 蛋白别名
- Interferon lambda receptor 1; IFN-lambda receptor 1; IFN-lambda-R1; Cytokine receptor class-II member 12; Cytokine receptor family 2 member 12; CRF2-12; Interleukin-28 receptor subunit alpha; IL-28 receptor subunit alpha; IL-28R-alpha; IL-28RA; Likely interleukin or cytokine receptor 2; LICR2
- 靶点基因名
- IFNLR1
- 基因别名
- IL28RA; LICR2
- UniProt
- Q8IU57
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Interferon lambda receptor 1 (IFNLR1), or IL28RA, is a type I transmembrane glycoprotein that pairs with IL10RB to form the functional receptor complex for type III interferons (IFN-λ). Predominantly expressed on epithelial cells, this receptor mediates antiviral and immunoregulatory signals through the JAK-STAT pathway, specifically activating STAT1 and STAT2. This restricted expression pattern allows IFNLR1 to orchestrate local immune responses at mucosal barriers without inducing systemic inflammation. Dysregulation of IFNLR1 signaling is associated with altered susceptibility to viral infections, such as hepatitis and Zika, and is implicated in inflammatory skin conditions like psoriasis.