人 ICOSLG 抗体对
01AB00271
Inducible T cell costimulator ligand (ICOSLG), also known as B7-H2 or B7RP-1, is a B7-related transmembrane glycoprotein that plays a crucial role in T cell activation and costimulation. It binds to the inducible T cell costimulator (ICOS) on activated T cells, delivering a positive costimulatory signal for optimal T cell function. Structurally, ICOSLG consists of extracellular IgV and IgC domains, with the IgV domain being essential for receptor binding and the IgC domain maintaining the protein's structural integrity. The receptor binding site on ICOSLG is primarily composed of aromatic/hydrophobic residues located on the GFCC'C'' beta-sheet face of the IgV domain, similar to the B7-1/B7-2 motifs that recognize CD28/CTLA-4. ICOSLG is involved in the T cell receptor signaling pathway and positively regulates interleukin-4 production. Its dysregulation can impact immune responses and potentially contribute to various immune-related disorders.
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技术参数
- 靶点基因名
- ICOSLG
- 基因别名
- B7H2; B7RP1; ICOSL; KIAA0653
- 蛋白别名
- inducible T cell costimulator ligand; ICOSLG
- UniProt
- O75144
- 物种
- Human
产品详情
- 靶点名称
- ICOSLG
- 蛋白名称
- inducible T cell costimulator ligand
- 蛋白别名
- ICOS ligand; B7 homolog 2; B7-H2; B7-like protein Gl50; B7-related protein 1; B7RP-1; CD antigen CD275
- 靶点基因名
- ICOSLG
- 基因别名
- B7H2; B7RP1; ICOSL; KIAA0653
- UniProt
- O75144
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Inducible T cell costimulator ligand (ICOSLG), also known as B7-H2 or B7RP-1, is a B7-related transmembrane glycoprotein that plays a crucial role in T cell activation and costimulation. It binds to the inducible T cell costimulator (ICOS) on activated T cells, delivering a positive costimulatory signal for optimal T cell function. Structurally, ICOSLG consists of extracellular IgV and IgC domains, with the IgV domain being essential for receptor binding and the IgC domain maintaining the protein's structural integrity. The receptor binding site on ICOSLG is primarily composed of aromatic/hydrophobic residues located on the GFCC'C'' beta-sheet face of the IgV domain, similar to the B7-1/B7-2 motifs that recognize CD28/CTLA-4. ICOSLG is involved in the T cell receptor signaling pathway and positively regulates interleukin-4 production. Its dysregulation can impact immune responses and potentially contribute to various immune-related disorders.