人 ICAM4 抗体对
01AB00845
Intercellular adhesion molecule 4 (ICAM4), also known as CD242 or the Landsteiner-Wiener (LW) blood group antigen, is a member of the immunoglobulin superfamily primarily expressed on erythroid cells. Structurally, ICAM4 contains two Ig-like C2-type domains and features extracellular, transmembrane, and cytoplasmic regions, with its extracellular domain facilitating interactions with leukocyte integrins such as LFA-1 (integrin alpha-L/beta-2), alpha-4/beta-1, and alpha-V integrins. This protein plays a critical role in cell adhesion processes, especially during erythroblast maturation and red blood cell development, thereby contributing to hematopoietic and immune system regulation. The molecular basis of the LW(A)/LW(B) blood group antigens is a single amino acid variation at position 100 (Gln-100 for LW(A), Arg-100 for LW(B)), and alternative splicing generates multiple isoforms. Clinically, mutations or variations in ICAM4 are linked to the Landsteiner-Wiener blood group system, with potential implications in transfusion medicine and rare hemolytic disease.
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技术参数
- 靶点基因名
- ICAM4
- 基因别名
- LW
- 蛋白别名
- intercellular adhesion molecule 4 (Landsteiner-Wiener blood group); ICAM4
- UniProt
- Q14773
- 物种
- Human
产品详情
- 靶点名称
- ICAM4
- 蛋白名称
- intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
- 蛋白别名
- Intercellular adhesion molecule 4; ICAM-4; Landsteiner-Wiener blood group glycoprotein; LW blood group protein; CD antigen CD242
- 靶点基因名
- ICAM4
- 基因别名
- LW
- UniProt
- Q14773
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Intercellular adhesion molecule 4 (ICAM4), also known as CD242 or the Landsteiner-Wiener (LW) blood group antigen, is a member of the immunoglobulin superfamily primarily expressed on erythroid cells. Structurally, ICAM4 contains two Ig-like C2-type domains and features extracellular, transmembrane, and cytoplasmic regions, with its extracellular domain facilitating interactions with leukocyte integrins such as LFA-1 (integrin alpha-L/beta-2), alpha-4/beta-1, and alpha-V integrins. This protein plays a critical role in cell adhesion processes, especially during erythroblast maturation and red blood cell development, thereby contributing to hematopoietic and immune system regulation. The molecular basis of the LW(A)/LW(B) blood group antigens is a single amino acid variation at position 100 (Gln-100 for LW(A), Arg-100 for LW(B)), and alternative splicing generates multiple isoforms. Clinically, mutations or variations in ICAM4 are linked to the Landsteiner-Wiener blood group system, with potential implications in transfusion medicine and rare hemolytic disease.