抗人 ICAM2 抗体对
01AB01162
Intercellular adhesion molecule 2 (ICAM2), also known as CD102, is a type I transmembrane glycoprotein belonging to the ICAM family, characterized by two immunoglobulin-like C2-type domains and primarily expressed on endothelial cells and some leukocytes. ICAM2 plays a crucial role in mediating adhesive interactions important for immune surveillance, including lymphocyte recirculation, antigen-specific immune responses, and NK cell-mediated clearance, by binding to leukocyte integrins such as LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). It also regulates spermatid adhesion on Sertoli cells, contributing to spermatogenesis. Beyond its physiological roles, ICAM2 has been implicated in disease contexts; it can suppress metastatic phenotypes in tumor cells by linking membrane proteins to the actin cytoskeleton, thereby impacting tumor cell motility and metastatic potential.
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技术参数
- 靶点基因名
- ICAM2
- 蛋白别名
- intercellular adhesion molecule 2; ICAM2
- UniProt
- P13598
- 物种
- Human
产品详情
- 靶点名称
- ICAM2
- 蛋白名称
- intercellular adhesion molecule 2
- 蛋白别名
- Intercellular adhesion molecule 2; ICAM-2; CD antigen CD102
- 靶点基因名
- ICAM2
- UniProt
- P13598
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Intercellular adhesion molecule 2 (ICAM2), also known as CD102, is a type I transmembrane glycoprotein belonging to the ICAM family, characterized by two immunoglobulin-like C2-type domains and primarily expressed on endothelial cells and some leukocytes. ICAM2 plays a crucial role in mediating adhesive interactions important for immune surveillance, including lymphocyte recirculation, antigen-specific immune responses, and NK cell-mediated clearance, by binding to leukocyte integrins such as LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). It also regulates spermatid adhesion on Sertoli cells, contributing to spermatogenesis. Beyond its physiological roles, ICAM2 has been implicated in disease contexts; it can suppress metastatic phenotypes in tumor cells by linking membrane proteins to the actin cytoskeleton, thereby impacting tumor cell motility and metastatic potential.