人 ICA1 抗体对
01AB03165
Islet cell autoantigen 1 (ICA1) is a protein encoded by the ICA1 gene, which is primarily expressed in pancreatic islet cells and plays a significant role in autoimmune responses. This protein contains an arfaptin homology domain, enabling it to participate in membrane trafficking and protein interactions within the Golgi complex and immature secretory granules. ICA1 is recognized as an autoantigen, particularly in insulin-dependent diabetes mellitus (Type 1 diabetes), where it can trigger an immune response that leads to the destruction of insulin-producing beta cells in the pancreas. Additionally, ICA1 has been implicated in primary Sjögren's syndrome, an autoimmune disorder characterized by dry mouth and eyes due to the immune-mediated damage of exocrine glands. Variations in the expression of ICA1 can influence susceptibility to these diseases, with certain polymorphisms associated with altered immune responses.
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技术参数
- 靶点基因名
- ICA1
- 蛋白别名
- islet cell autoantigen 1; ICA1
- UniProt
- Q05084
- 物种
- Human
产品详情
- 靶点名称
- ICA1
- 蛋白名称
- islet cell autoantigen 1
- 蛋白别名
- Islet cell autoantigen 1; 69 kDa islet cell autoantigen; ICA69; Islet cell autoantigen p69; ICAp69; p69
- 靶点基因名
- ICA1
- UniProt
- Q05084
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Islet cell autoantigen 1 (ICA1) is a protein encoded by the ICA1 gene, which is primarily expressed in pancreatic islet cells and plays a significant role in autoimmune responses. This protein contains an arfaptin homology domain, enabling it to participate in membrane trafficking and protein interactions within the Golgi complex and immature secretory granules. ICA1 is recognized as an autoantigen, particularly in insulin-dependent diabetes mellitus (Type 1 diabetes), where it can trigger an immune response that leads to the destruction of insulin-producing beta cells in the pancreas. Additionally, ICA1 has been implicated in primary Sjögren's syndrome, an autoimmune disorder characterized by dry mouth and eyes due to the immune-mediated damage of exocrine glands. Variations in the expression of ICA1 can influence susceptibility to these diseases, with certain polymorphisms associated with altered immune responses.